目的 探讨荜铃胃痛颗粒联合兰索拉唑治疗慢性浅表性胃炎的安全性和有效性。方法 选取2017年7月—2018年2月在杨陵示范区医院就诊的慢性浅表性胃炎患者120例，随机分成对照组（60例）和治疗组（60例）。对照组患者口服兰索拉唑肠溶片，1片/次，1次/d；治疗组患者在对照组的基础上口服荜铃胃痛颗粒，1袋/次，3次/d。两组患者均连续治疗6周。观察两组患者临床疗效，同时比较治疗前后两组患者视觉模拟评分（VAS）、日常生活能力量表（ADL）评分、前列腺素E2（PGE2）和表皮细胞生长因子（EGF）水平及不良反应情况。结果 治疗后，对照组和治疗组临床总有效率分别为81.67%和95.00%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者VAS较治疗前显著降低（P<0.05），ADL评分显著升高（P<0.05），且治疗后治疗组VAS和ADL评分明显优于对照组（P<0.05）。治疗后，两组患者PGE2较治疗前均显著升高（P<0.05），EGF水平显著降低（P<0.05），且治疗后治疗组PGE2和EGF水平明显优于对照组（P<0.05）。治疗期间，治疗组不良反应发生率为3.33%，明显低于对照组的15.00%，两组比较差异具有统计学意义（P<0.05）。结论 荜铃胃痛颗粒联合兰索拉唑治疗慢性浅表性胃炎疗效显著，可显著改善患者生活质量，具有一定的临床推广应用价值。

Objective To investigate the safety and efficacy of Biling Weitong Granules combined with lansoprazole in treatment of chronic superficial gastritis. Methods Patients (120 cases) with chronic superficial gastritis in Yangling Demonstration Zone Hospital from July 2017 to February 2018 were randomly divided into control (60 cases) and treatment (60 cases) groups. Patients in the control group were po administered with Lansoprazole Enteric-coated Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Biling Weitong Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacy was evaluated, and VAS, ADL scores, PGE2 and EGF levels, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 81.67% and 95.00%, respectively, and there were differences between two groups (P<0.05). After treatment, VAS in two groups was significantly decreased (P<0.05), but ADL scores was significantly increased (P<0.05), and the VAS and ADL scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the PGE2 levels in two groups were significantly increased (P<0.05), but EGF levels were significantly decreased (P<0.05), and the PGE2 and EGF levels in the treatment group were significantly better than those in the control group (P<0.05). During the treatment, the adverse reactions rate in the treatment group was 3.33%, which was significantly lower than 15.00% in the control group, with significant difference between two groups (P<0.05). Conclusion Biling Weitong Granules combined with lansoprazole has significant clinical effect on chronic superficial gastritis, can significantly improve the quality of life, which has a certain clinical application value.