目的 研究酒石酸美托洛尔片联合心脉隆注射液治疗慢性心力衰竭的临床效果。方法 选取2017年1月—2018年1月北京市房山区第一医院治疗的92例慢性心力衰竭患者作为研究对象，将所有患者随机分为对照组和治疗组，每组各46例。对照组静脉滴注心脉隆注射液，6 mL加入0.9%氯化钠无菌溶液250 mL中，2次/d。治疗组患者在对照组治疗的基础上口服酒石酸美托洛尔片，初始剂量6.25 mg/次，2次/d。根据病情剂量增加至6.25～12.5 mg/次，最大剂量低于100 mg/d。7 d作为1个疗程，两组患者连续治疗4个疗程。观察两组临床疗效，同时比较治疗前后两组的左室射血分数（LVEF）、左心室收缩末期内径（LVESD）、左心室舒张末期内径（LVEDD）、6 min步行距离和血脑钠肽水平。结果 治疗后，治疗组总有效率为91.3%，显著高于对照组的80.4%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者LVEF明显升高，LVESD、LVEDD明显降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组患者左心室功能指标明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者6 min步行距离显著增加，BNP水平显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组6 min步行距离、BNP水平显著优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 酒石酸美托洛尔片联合心脉隆注射液治疗慢性心力衰竭的疗效显著，可改善患者心功能，且安全性较高，具有一定的临床推广应用价值。

Objective To study the clinical effect of Metoprolol Tartrate Tablets combined with Xinmailong Injection in treatment of chronic heart failure. Methods Patients (92 cases) with chronic heart failure in the First Hospital of Fangshan District, Beijing from January 2017 to January 2018 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were iv administered with Xinmailong Injection, 6 mL added into 0.9% NaCl solution 250 mL, twice daily. Patients in the treatment group were po administered with Metoprolol Tartrate Tablets on the basis of the control group, and the starting dosage was 6.25 mg/time, twice daily. The dosage increased to 6.25-12.5 mg/time according to the condition, and the maximum dose was less than 100 mg/d. One course of treatment had 7 d, and patients in two groups were treated for 4 courses. After treatment, the clinical efficacy was evaluated, and LVEF, LVESD, LVEDD, 6 min walking distance, and BNP levels in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the treatment group was 91.3%, which was significantly higher than 80.4% in the control group, and there were differences between two groups (P<0.05). After treatment, LVEF in two groups were significantly increased, but LVESD and LVEDD in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, left ventricular function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, 6 min walking distance in two groups were significantly increased, but BNP levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the 6 min walking distance and BNP levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Metoprolol Tartrate Tablets combined with Xinmailong Injection has significant clinical efficacy in treatment of chronic heart failure, can improve the cardiac function of patients, with higher safety, which has a certain clinical application value.