目的 探讨法舒地尔联合纳洛酮治疗外伤性脑梗死的临床疗效。方法 选择2013年1月—2018年1月山东省立第三医院收治的外伤性脑梗死患者110例，随机分为对照组和治疗组，每组各55例。对照组静脉滴注盐酸纳洛酮注射液，0.8 mg加入250 mL生理盐水，1次/d。治疗组在对照组基础上静脉滴注盐酸法舒地尔注射液，30 mg加入250 mL生理盐水，1次/d。两组患者连续治疗14 d。观察两组患者临床疗效，同时比较治疗前后两组患者神经功能和运动功能FM评分。结果 治疗后，对照组和治疗组临床有效率分别为76.36%和92.73%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者Barthel指数和欧洲版神经功能缺损评分（ESS）评分均显著升高（P<0.05），美国国立卫生研究卒中量表（NIHSS）显著降低（P<0.05），且治疗组神经功能评分明显优于对照组（P<0.05）。治疗后，两组患者上肢和下肢及总评分均显著升高（P<0.05），且治疗组患者治疗后运动功能FM评分明显高于对照组（P<0.05）。结论 法舒地尔联合纳洛酮治疗外伤性脑梗死能够显著提高临床疗效，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of fasudil combined with naloxone in treatment of traumatic cerebral infarction. Methods Patients (110 cases) with traumatic cerebral infarction in Shandong Province Third Hospital from January 2013 to January 2018 were randomly divided into control and treatment groups, and each group had 55 cases. Patients in the control group were iv administered with Naloxone Hydrochloride Injection, 0.8 mg added into 250 mL normal saline, once daily. Patients in the treatment group were iv administered with Fasudil Hydrochloride Injection on the basis of the control group, 30 mg added into 250 mL normal saline, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the neurological function and the motor function FM scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 76.36% and 92.73%, respectively, and there were differences between two groups (P<0.05). After treatment, the Barthel and ESS scores in two groups were significantly increased (P<0.05), but the NIHSS score in two groups was significantly decreased (P<0.05), and the neurological function scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the upper and lower extremities scores and total scores in two groups were significantly increased (P<0.05), and the motor function FM scores in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion Fasudil combined with naloxone in treatment of traumatic cerebral infarction can significantly improve the clinical efficacy, which has a certain clinical application value.