目的 调查分析2015-2017年西安市中心医院质子泵抑制剂的使用情况，为临床合理用药提供参考。方法 抽取西安市中心医院2015-2017年质子泵抑制剂的相关使用数据，对销售金额、用药频度（DDDs）、日均费用（DDC）、药品排序比（B/A）等指标进行统计和分析。结果 质子泵抑制剂的销售金额总体呈下降趋势，口服剂型PPIs的用药金额及构成比逐年下降，而注射剂型PPIs的用药金额有所下降，构成比小幅增长；用药金额排前3位的科室分别为消化内科、血研所和普外Ⅱ科。注射用泮托拉唑、注射用兰索拉唑和奥美拉唑冻干粉的DDDs居前3位；DDC最高的为埃索美拉唑冻干粉，最低为奥美拉唑肠溶胶囊（20 mg）。大多数药品的B/A值介于0.5~1.5，同步性较好。结论 质子泵抑制剂在西安市中心医院的应用十分广泛，但同时也存在一些不合理用药的情况，需持续改进。

Objective To investigate and analyze current status of proton pump inhibitors (PPIs) in Xi'an Central Hospital from 2015 to 2017, so as to provide reference for rational use of PPIs. Methods The data of the clinical use of PPIs were collected in Xi'an Central Hospital from 2015 to 2017. Then, the rationality of these drugs was evaluated in terms of consumption sum, defined daily dosed (DDDs), defined daily cost (DDC), and drug sequence ration (B/A). Results Consumption sum of PPIs had the trend of decrease on the whole, and consumption sum of oral PPIs and the ratio to total cost of drugs increased year by year. While consumption sum of PPIs for injection were decreased, but the proportion was increased slightly. The top 3 departments of PPIs in consumption sum were Department of Digestive, Hematologists, and General surgery Ⅱ. DDDs of Pantoprazole Sodium for injection, Lansoprazole for injection, and Omeprazole for injection ranked the top three. DDC of Esomeprazole for injection was the highest, while DDC of Omeprazole Enteric-coated Capsules (20 mg) was the lowest. B/A of most drugs were between 0.5 and 1.5, indication that the synchronism was better. Conclusion PPIs are widely applied in Xi'an Central Hospital, but there are also some irrational drug use situations, which need continuous improvement.