目的 探讨清热暗疮片联合阿达帕林凝胶治疗痤疮的临床疗效。方法 选取2016年7月-2017年12月青海省中医院收治的痤疮患者163例，随机分为对照组（81例）和对照组（82例）。对照组患处涂抹阿达帕林凝胶，1次/d。治疗组患者在对照组基础上口服清热暗疮片，2片/次，3次/d。两组患者均连续治疗14 d。观察两组患者临床疗效，同时比较治疗前后两组患者皮损数目和满意度评分。结果 治疗后，对照组和治疗组临床有效率分别为69.14和91.46%，两组比较差异具有统计学意义（P<0.05）。治疗后，对照组丘疹和脓疱明显减少，治疗组丘疹、脓疱、粉刺、结节囊肿显著减少，同组比较差异具有统计学意义（P<0.05）；且治疗后治疗组粉刺、丘疹、脓疱、结节囊肿个数均比对照明显减少，两组比较差异具有统计学意义（P<0.05）。治疗2、4、6和8周后，两组患者满意度评分比治疗前均明显提高，同组比较差异具有统计学意义（P<0.05）；且治疗后治疗组患者第4、6和8周满意度评分明显高于同期对照组，两组比较差异具有统计学意义（P<0.05）。结论 清热暗疮片联合阿达帕林凝胶治疗痤疮疗效显著，可有效降低患者痤疮的皮损数目，不良反应少，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Qingre Anchuang Tablets combined with Adapalene Gel in treatment of acne. Methods Patients (163 cases) with acne in Qinghai Provincial Hospital of TCM from July 2016 to December 2017 were randomly divided into control (81 cases) and treatment (82 cases) groups, and each group had 58 cases. Patients in the control group were given administered with Adapalene Gel, once a night. Patients in the treatment group were po administered with Qingre Anchuang Tablets on the basis of the control group, 2 tablets/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the number of skin lesions and the satisfaction scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 69.14 and 91.46% respectively, and there were differences between two groups (P<0.05). After treatment, papules and pustules in the control group were significantly decreased, papules, pustules, acne and nodular cysts in the treatment group were significantly decreased, and there were differences in the same group (P<0.05). After treatment, papules, pustules, acne and nodular cysts in the treatment group were significantly less than those in the control group, with significant difference between two groups (P<0.05). After treatment for 2, 4, 6, and 8 weeks, the satisfaction scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05), and the scores of 4, 6, and 8 weeks in the treatment group after treatment were significantly higher than those in the control group in the same period, with significant difference between two groups (P<0.05). Conclusion Qingre Anchuang Tablets combined with Adapalene Gel in treatment of acne has significant efficacy with less adverse reaction, can effectively decrease the number of skin lesions, which has a certain clinical application value.