目的 评价麒麟丸联合炔雌醇环丙孕酮片治疗多囊卵巢综合征致不孕症的临床疗效和安全性。方法 选取2014年7月-2015年7月鄂州市中医医院收治的多囊卵巢综合征致不孕症患者121例为研究对象，随机将所有患者分为对照组（60例）和治疗组（61例）。对照组口服炔雌醇环丙孕酮片，于月经自然周期第5天开始服药，1片/次，1次/d；治疗组在对照组治疗的基础上口服麒麟丸，6 g/次，3次/d。两组患者均连续治疗3个月经周期。观察两组患者妊娠率和排卵率，同时比较治疗前后两组的性激素、胰岛素、基质金属蛋白酶9（MMP-9）、肝细胞生长因子（HGF）水平、子宫内膜厚度和不良反应发生情况。结果 治疗后，对照组和治疗组患者的妊娠率分别为31.67%、52.46%，两组比较差异有统计学意义（P<0.05）。治疗后，对照组和治疗组患者的排卵率分别为75.00%、91.80%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者的黄体生成激素、胰岛素水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）。治疗后，治疗组黄体生成激素、胰岛素水平均显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的MMP-9、HGF水平均显著降低，子宫内膜厚度显著增加，同组治疗前后比较差异具有统计学意义（P<0.05）。治疗后，治疗组MMP-9、HGF水平和子宫内膜厚度显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，对照组和治疗组患者的不良反应发生率分别为18.33%、4.92%，两组比较差异有统计学意义（P<0.05）。结论 麒麟丸联合炔雌醇环丙孕酮片治疗多囊卵巢综合征致不孕症具有较好的临床疗效，调节性激素和胰岛素水平，降低血清因子水平，增加子宫内膜厚度，安全性高，具有一定的临床推广应用价值。

Objective To evaluate the clinical efficacy and safety of Qilin Pills combined with Ethinylestradiol and Cyproterone Acetate Tablets in treatment of infertility caused by polycystic ovarian syndrome. Methods Women (121 cases) with infertility caused by polycystic ovarian syndrome in Ezhou Hospital of Traditional Chinese Medicine from July 2014 to July 2015 were randomly divided into control (60 cases) and treatment (61 cases) groups. Women in the control group were po administered with Ethinylestradiol and Cyproterone Acetate Tablets, began on the fifth day of the menstrual cycle, 1 tablet/time, once daily. Women in the treatment group were po administered with Qilin Pills on the basis of the control group, 6 g/time, three times daily. Women in two groups were treated for 3 menstrual cycles. After treatment, the rates of pregnancy and ovulation were evaluated, and sex hormones, insulin, MMP-9, HGF levels and the endometrial thickness in two groups before and after treatment were compared. Results After treatment, the pregnancy rates in the control and treatment groups were 31.67% and 52.46%, respectively, and there was difference between two groups (P<0.05). After treatment, the ovulation rates in the control and treatment groups were 75.00% and 91.80%, respectively, and there was difference between two groups (P<0.05). After treatment, luteinizing hormone and insulin levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, luteinizing hormone and insulin levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the MMP-9, and HGF levels in two groups were significantly decreased, but endometrial thickness were significantly increased, and there were differences in the same group (P<0.05). After treatment, the MMP-9, HGF levels and endometrial thickness in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the adverse reactions rates in the control and treatment groups were 18.33% and 4.92%, respectively, and there was difference between two groups (P<0.05). Conclusion Qilin Pills combined with Ethinylestradiol and Cyproterone Acetate Tablets has clinical curative effect in treatment of infertility caused by polycystic ovarian syndrome, can regulate sex hormones and insulin levels, lower serum factor levels, and increases endometrial thickness, with high safety, which has a certain clinical application value.