目的 探究他氟前列素滴眼液联合盐酸卡替洛尔滴眼液治疗开角型青光眼的临床疗效。方法 选取2016年4月-2017年4月于宝鸡市人民医院治疗的80例（146眼）高眼压型原发性开角型青光眼患者为研究对象，根据数字表法将患者分为对照组（40例72眼）和治疗组（40例74眼）。对照组给予盐酸卡替洛尔滴眼液，1滴/次，2次/d。治疗组在对照组基础上给予他氟前列素滴眼液，1滴/次，1次/d。4周为1个疗程，两组均治疗3个疗程。观察两组患者的临床疗效，比较治疗前后两组患者的视盘参数、杯盘直径比、角膜中央厚度、前房深度和眼压。结果 治疗后，对照组和治疗组的改善率分别为80.56%、97.30%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者盘沿面积（RA）、盘沿容积（RV）和视盘容积（DV）指数均显著升高，同组治疗前后比较差异具有统计学意义（P<0.05）。治疗后，治疗组的视盘参数显著高于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者水平杯盘直径比（C/D）显著升高，垂直C/D显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）。治疗后，治疗组的杯盘直径比改善程度显著优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组角膜中央厚度均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）。治疗后，治疗组的角膜中央厚度显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者眼压均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）。治疗后，治疗组眼压显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 他氟前列素滴眼液联合盐酸卡替洛尔滴眼液治疗开角型青光眼患者具有较好的临床疗效，可有效提高患者视力，改善视盘参数和视网膜神经纤维层厚度，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Tafluprost Eye Drops combined with Carteolol Hydrochloride Eye Drops in treatment of open angle glaucoma. Methods Patients (80 cases, 146 eyes) with high intraocular pressure primary open angle glaucoma in Baoji People's Hospital from April 2016 to April 2017 were randomly divided into control (40 cases, 72 eyes) and treatment (40 cases, 74 eyes) groups. Patients in the control group were given Carteolol Hydrochloride Eye Drops, 1 drop/time, twice daily. Patients in the treatment group were given Tafluprost Eye Drops on the basis of the control group,, 1 drop/time, once daily. One course had 4 weeks, and patients in two groups were treated for 3 courses. After treatment, the clinical efficacies were evaluated, and the optic disc parameters, cup and disk diameter ratio, central corneal thickness, anterior chamber depth, and intraocular pressure in two groups before and after treatment were compared. Results After treatment, the improvement rate in the control and treatment group were 80.56% and 97.30%, respectively, and there were differences between two groups (P<0.05). After treatment, RA, RV, and DV in two groups were significantly increased, and there were differences in the same group (P<0.05). After treatment, the optic disc parameters in the treatment group were higher than those in the control group, and there were differences between two groups (P<0.05). After treatment, horizontal C/D in two groups was significantly increased, but vertical C/D in two groups was significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the cup and disk diameter ratio in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, central corneal thickness in two groups was significantly decreased, and there were differences in the same group (P<0.05). After treatment, the central corneal thickness in the treatment group waslower than those in the control group, and there were differences between two groups (P<0.05). After treatment, intraocular pressures in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the intraocular pressures in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). Conclusion Tafluprost Eye Drops combined with Carteolol Hydrochloride Eye Drops has significant clinical effect in treatment of open angle glaucoma, can effectively improve the patient's vision, improve optic disc parameters and thickness of retinal nerve fibers, which has a certain clinical application value.