目的 探讨银杏物提取物注射液联合甲磺酸倍他司汀片治疗突发性耳聋的临床疗效。方法 选取2016年9月-2017年9月于新疆医科大学第二附属医院治疗的突发性耳聋患者86例作为研究对象，采用双色球法随机将患者分为对照组和治疗组，每组各43例。对照组口服甲磺酸倍他司汀片，6 mg/次，3次/d。治疗组在对照组基础上静脉滴注银杏叶提取物注射液，将87.5 mg银杏叶提取物注射液加入250 mL生理盐水中，1次/d。两组患者均持续治疗10 d。观察两组患者的临床疗效，同时比较治疗前后两组的听阈水平和血液流变学指标。结果 治疗后，对照组和治疗组的总有效率分别为76.7%、90.7%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者听阈水平均明显下降，同组治疗前后比较差异具有统计学意义（P<0.05）。治疗后，治疗组听阈水平显著低于照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的全血高切黏度、全血低切黏度、血浆黏度和血小板聚集率水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）。治疗后，治疗组血液流变学指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 银杏叶提取物注射液联合甲磺酸倍他司汀片治疗突发性耳聋具有较好的临床疗效，能显著改善患者听阈水平和血液流变学指标，且不良反应低，具有一定的临床推广应用价值。

Objective To investigate the clinical effects of Extract of Ginkgo Biloba Leaves Injection combined with Betahistine Mesilate Tablets in treatment of sudden deafness. Methods Patients (86 cases) with sudden deafness in the Second Affiliated Hospital of Xinjiang Medical University from September 2016 to September 2017 were randomly divided into control and treatment groups by the double chromosphere method, and each group had 43 cases. Patients in the control group were po administered with Betahistine Mesilate Tablets, 6 mg/time, three times daily. Patients in the treatment group were iv administered with Extract of Ginkgo Biloba Leaves Injection on the basis of the control group, 87.5 mg added into normal saline 250 mL, once daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the hearing threshold levels and hemorheology indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 76.7% and 90.7%, respectively, and there were differences between two groups (P<0.05). After treatment, the hearing threshold levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the hearing threshold levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, and platelet aggregation in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, hemorheology indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Extract of Ginkgo Biloba Leaves Injection combined with Betahistine Mesilate Tablets has clinical curative effect in treatment of sudden deafness, can significantly improve the hearing threshold level and hemorheology indexes, with lower adverse reactions, which has a certain clinical application value.