目的 研究六神丸联合硫酸庆大霉素注射液治疗口腔溃疡的临床疗效。方法 选取天津医科大学第二医院2015年8月-2017年8月收治的口腔溃疡患者120例，将所有患者随机分为对照组和治疗组，每组各60例。对照组患者给予硫酸庆大霉素注射液，将稀释好的硫酸庆大霉素注射液用棉球蘸取后，直接涂在患者溃疡部位，1 min/次，4次/d。治疗组患者在对照组治疗的基础上给予六神丸，将10丸六神丸溶解在2 mL温水中嗽口，取适量用无菌棉签涂在溃疡面上，2 min/次，4次/d。7 d为1个疗程，两组患者连用14 d。观察两组患者的临床疗效，比较治疗前后两组的视觉模拟量表（VAS）评分、唾液内生化指标水平。结果 治疗后，对照组和治疗组的总有效率分别为83.33%、96.67%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者VAS评分显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组VAS评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组肿瘤坏死因子（TNF-α）和白细胞介素-6（IL-6）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组生化指标水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 六神丸联合硫酸庆大霉素注射液治疗口腔溃疡具有较好的临床疗效，能显著改善患者疼痛症状，降低炎性因子水平，安全性较高，具有一定的临床推广应用价值。

Objective To study the clinical effect of Liushen Pills combined with Gentamycin Sulfate Injection in treatment of oral ulcer. Methods Patients (120 cases) with oral ulcer in the Second Hospital of Tianjin Medical University from August 2015 to August 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were administered with Gentamycin Sulfate Injection after diluted, dipped with cotton balls and applied directly to the ulcer part of the patient, 1 min/time, four times daily. Patients in the treatment group were administered with Liushen Pills, 10 pills dissolved into 2 mL warm water to rinse the mouth, and applied appropriate amount to the ulcer with a sterile cotton swab, 2 min/time, four times daily. One course had 7 d, and patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the VAS scores and biochemical indexes levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.33% and 96.67%, respectively, and there were differences between two groups (P<0.05). After treatment, the VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the VAS scores in the treatment group were significantly lower than that in the control group, with significant difference between two groups (P<0.05). After treatment, the TNF-α, IL-6 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the levels of biochemical indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Liushen Pills combined with Gentamycin Sulfate Injection has good clinical effect in treatment of oral ulcer, can significantly improve the pain symptoms of patients, and reduce the levels of inflammatory factors, with good safety, which has a certain clinical application value.