目的 探讨口炎清颗粒联合布地奈德气雾剂治疗慢性咽炎的临床疗效。方法 选取2016年2月-2017年9月武汉大学中南医院收治的79例慢性咽炎患者为研究对象，所有患者按照数字表法随机分为对照组（39例）和治疗组（40例）。对照组吸入布地奈德气雾剂，0.5 mg/次，3次/d。治疗组对照组治疗的基础上口服口炎清颗粒，6 g/次，2次/d。两组患者均持续治疗3周。观察两组临床疗效，同时比较两组的临床症状改善时间和不良反应发生情况。结果 治疗后，对照组和治疗组的总有效率分别为84.6%、92.5%，两组治疗比较差异具有统计学意义（P<0.05）。治疗后，治疗组咽喉肿痛、咳嗽咳痰、咽部异物感、分泌物改善时间明显短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗期间，对照组不良反应发生率为28.2%，明显高于治疗组的10.0%，两组比较差异具有统计学意义（P<0.05）。结论 口炎清颗粒联合布地奈德气雾剂治疗慢性咽炎疗效确切，能够有效改善患者临床症状，且无严重不良反应，值得临床推广运用。

Objective To explore the clinical effect of Kouyanqing Granules combined with Budesonide Aerosol in treatment of chronic pharyngitis. Methods Patients (79 cases) with chronic pharyngitis in Zhongnan Hospital of Wuhan University from February 2016 to September 2017 were randomly divided into control (39 cases) and treatment (40 cases) groups. Patients in the control group were inhalation administered with Budesonide Aerosol, 0.5 mg/time, three times daily. Patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group, 6 g/time, twice daily. Patients in two groups were treated for 3 weeks. After treatment, the clinical efficacies were evaluated, and the improvement times of clinical symptoms and adverse reactions in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.6% and 92.5%, respectively, and there was difference between two groups (P<0.05). After treatment, the improvement time of sore throat, cough and expectoration, pharyngeal foreign body sensation, and secretion in the treatment group were shorter than those in the control group, and there were differences between two groups (P<0.05). During the treatment, the adverse reaction rates in the control group was 28.2%, which was significantly higher than 10.0% in the treatment group, with significant difference between two groups (P<0.05). Conclusion Kouyanqing Granules combined with Budesonide Aerosol has significant curative effect in treatment of chronic pharyngitis, can effectively improve the clinical symptoms of patients, without serious adverse reactions, which has a certain clinical application value.

湖北省卫生厅科研项目（WJ2015MB036）