目的 探讨黄连上清胶囊联合盐酸米诺环素软膏治疗慢性牙周炎的临床疗效。方法 选取2016年7月-2017年9月北京市顺义区医院收治的慢性牙周炎患者80例（患牙95颗），随机分为对照组和治疗组，每组各40例，患牙分别为48、47颗。对照组患部牙周袋内注满盐酸米诺环素软膏，1次/周。治疗组在对照组治疗的基础上口服黄连上清胶囊，4粒/次，2次/d。两组患者均连续治疗4周。观察两组的临床疗效，比较两组的牙周指标和炎症因子水平。结果 治疗后，对照组和治疗组的总有效率分别为79.17%、91.49%，两组比较差异有统计学意义（P<0.05）。治疗后，两组菌斑指数（PLI）、龈沟出血指数（SBI）、牙周袋深度（PD）和牙龈指数（GI）均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组牙周指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-1β（IL-1β）水平均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组炎症因子水平明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 黄连上清胶囊联合盐酸米诺环素软膏治疗慢性牙周炎具有较好的临床疗效，可改善牙周指标，调节炎症因子水平，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Huanglian Shangqing Capsules combined with Minocycline Hydrochloride Ointment in treatment of chronic periodontitis. Methods Patients (80 cases and 95 teeth) with chronic periodontitis in the Hospital of Shunyi District Beijing from July 2016 to September 2017 were randomly divided into control and treatment groups, and each group had 40 cases with diseased teeth 48 and 47 teeth, respectively. The periodontal pockets of the diseased teeth in the control group were filled with Minocycline Hydrochloride Ointment, once weekly. Patients in the treatment group were po administered with Huanglian Shangqing Capsules on the basis of the control group, 4 grains/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and periodontal indexes and inflammatory factors levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.17% and 91.49%, respectively, and there was difference between two groups (P<0.05). After treatment, PLI, SBI, PD, and GI in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the periodontal indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of TNF-α, IL-6, and IL-1β in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the inflammatory factors levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Huanglian Shangqing Capsules combined with Minocycline Hydrochloride Ointment has clinical curative effect in treatment of chronic periodontitis, can improve periodontal indexes and regulate inflammatory factors levels, which has a certain clinical application value.