目的 观察四磨汤口服液联合比沙可啶治疗老年功能性便秘的临床疗效。方法 选取2017年1月-2017年12月在秦皇岛军工医院就诊的患者106例，随机分为对照组和治疗组，每组各53例。对照组口服比沙可啶肠溶片，5 mg/次，1次/d。治疗组在对照组治疗基础上口服四磨汤口服液，20 mL/次，3次/d。两组均连续治疗4周。观察两组的临床疗效，比较两组治疗前后排便间隔时间、排便时长的变化情况。随访6个月，观察两组的复发情况。结果 治疗后，对照组和治疗组的总有效率分别为75.47%、90.57%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者排便间隔时间、排便时长均较治疗前显著缩短，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组排便间隔时间、排便时长均显著短于对照组，两组比较差异具有统计学意义（P<0.05）。随访6个月，对照组和治疗组的复发率分别为58.49%、32.08%，两组比较差异具有统计学意义（P<0.05）。结论 四磨汤口服液联合比沙可啶治疗老年功能性便秘具有较好的临床疗效，可缩短患者排便间隔时间和排便时间，降低复发率，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Simotang Oral Liquid combined with bisacodyl in treatment of elderly functional constipation. Methods Patients (106 cases) with elderly functional constipation in Qinhuangdao Military Hospital from January 2017 to December 2017 were randomly divided into control (53 cases) and treatment (53 cases) groups. Patients in the control group were po administered with Bisacodyl Enteric-coated Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Simotang Oral Liquid on the basis of the control group, 20 mL/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the changes of defecation interval and defecation time in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 75.47% and 90.57%, and there were differences between two groups (P<0.05). After treatment, defecation interval and defecation time in two groups were significantly shorter than those before treatment, and there were differences in the same group (P<0.05). After treatment, defecation interval and defecation time in the treatment group were shorter than those in the control group, and there were differences between two groups (P<0.05). Followed up for 6 months, the recurrence rates in the control and treatment group were 58.49% and 32.08%, and there were differences between two groups (P<0.05). Conclusion Simotang Oral Liquid combined with bisacodyl has significant clinical effect in treatment of elderly functional constipation, and can shorten defecation interval and defecation time, which has a certain clinical application value.

秦皇岛市市级科技计划（第三批）自筹经费项目（201703A125）