目的 探讨参地益阴胶囊联合维格列汀片治疗2型糖尿病的临床疗效。方法 选取2017年2月-2018年2月在西安市第九医院治疗的2型糖尿病患者92例，根据用药的差别分为对照组（46例）和治疗组（46例）。对照组口服维格列汀片，50 mg/次，2次/d；治疗组在对照组基础上口服参地益阴胶囊，4粒/次，3次/d。两组患者均治疗3个月。观察两组患者临床疗效，同时比较治疗前后两组患者血糖相关指标、血清学指标和氧化应激指标。结果 治疗后，对照组临床有效率为80.43%，显著低于治疗组的95.65%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组空腹血糖（FBG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）水平均显著降低（P<0.05），且治疗组这些血糖相关指标比对照组降低更明显（P<0.05）。治疗后，两组血小板源性生长因子（PGRN）、γ-谷氨酰转肽酶（γ-GT）、转化生长因子-β1（TGF-β1）水平均显著降低（P<0.05），分泌型卷曲相关蛋白5（SFRP5）水平显著增加（P<0.05），且治疗后治疗组这些血清学指标明显优于对照组（P<0.05）。治疗后，两组谷胱甘肽过氧化物酶（GSH-PX）、超氧化物歧化酶（SOD）水平均显著升高（P<0.05），丙二醛（MDA）水平显著降低（P<0.05），且治疗后治疗组上述氧化应激指标改善程度明显优于对照组（P<0.05）。结论 参地益阴胶囊联合维格列汀片治疗2型糖尿病可有效降低机体炎症反应，改善氧化应激状态，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Shendi Yiyin Capsules combined with vildagliptin in treatment of type 2 diabetes mellitus. Methods Patients (92 cases) with type 2 diabetes mellitus in the Ninth Hospital of Xi'an from February 2017 to February 2018 were divided into control (46 cases) and treatment (46 cases) groups based on different treatments. Patients in the control group were po administered with Vildagliptin Tablets, 50 mg/time, twice daily. Patients in the treatment group were po administered with Shendi Yiyin Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the blood glucose related indexes, the serological indexes, the oxidative stress indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.43%, which was significantly lower than 95.65% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the FPG, 2 h PG, HbAlc, and FINS in two groups were significantly decreased (P<0.05), and these blood glucose related indexes in the treatment group after treatment were significantly lower than those in the control group (P<0.05). After treatment, the PGRN, γ-GT, and TGF-β1 levels in two groups were significantly decreased (P<0.05), but SFRP5 levels were significantly increased (P<0.05), and these serological indexes in the treatment group after treatment were significantly better than those in the control group (P<0.05). After treatment, the GSH-Px and SOD levels in two groups were significantly increased (P<0.05), but MDA levels were significantly decreased (P<0.05), and these oxidative stress indexes in the treatment group after treatment were significantly better than those in the control group (P<0.05). Conclusion Shendi Yiyin Capsules combined with vildagliptin in treatment of type 2 diabetes mellitus can effectively reduce the inflammatory response and improve the oxidative stress state, which has a certain clinical application value.