目的 探讨安宫降压丸联合厄贝沙坦片治疗原发性高血压的临床疗效。方法 选取2017年4月-2018年4月在宝鸡市中心医院接受治疗的原发性高血压患者90例，根据用药的差别分为对照组（45例）和治疗组（45例）。对照组口服厄贝沙坦片，起始剂量0.15 g/次，1次/d，根据病情增至0.3 g/次，1次/d。治疗组在对照组基础上口服安宫降压丸，6 g/次，2次/d。两组患者均治疗4周。观察两组患者临床疗效，同时比较治疗前后两组患者血压变化、生活质量评分和血清学指标。结果 治疗后，对照组临床有效率为80.00%，显著低于治疗组的97.78%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组24 h mSBP和24 h mDBP均显著降低（P<0.05），且治疗后治疗组24 h mSBP和24 h mDBP水平明显优于对照组（P<0.05）。治疗后，两组生理功能、心理功能、社会关系和环境领域评分均显著升高（P<0.05），且治疗后治疗组各生活质量评分明显高于对照组（P<0.05）。治疗后，两组血清可溶性凝集素样氧化低密度脂蛋白受体1（sLOX-1）、单核细胞趋化蛋白1（MCP-1）、转化生长因子β1（TGF-β1）和内皮素-1（ET-1）水平均显著降低，一氧化氮（NO）水平显著升高，同组治疗前后比较差异具有统计学意义（P<0.05），且治疗后治疗组上述血清学指标明显优于对照组（P<0.05）。结论 安宫降压丸联合厄贝沙坦片治疗原发性高血压临床疗效好，有利于提高患者生活质量，具有一定的临床推广应用价值。

Objective To explore the clinical efficacy of Angong Jiangya Pills combined with irbesartan in treatment of primary hypertension. Methods Patients (90 cases) with primary hypertension in Baoji Central Hospital from April 2017 to April 2018 were divided into control (45 cases) and treatment (45 cases) groups based on different treatments. Patients in the control group were po administered with Irbesartan Tablets, the initial dose was 0.15 g/time, once daily, and increased to 0.3 g/time in accordance with the condition of diseases, once daily. Patients in the treatment group were po administered with Angong Jiangya Pills on the basis of the control group, 6 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and blood pressure changes, the quality of life scores, the serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.00%, which was significantly lower than 97.78% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the 24 h mSBP and 24 h mDBP in two groups were significantly decreased (P<0.05), and which 24 h mSBP and 24 h mDBP in the treatment group after treatment were significantly better than those in the control group (P<0.05). After treatment, the physiologic function, mental function, social relationship, and environment scores in two groups were significantly increased (P<0.05), and the quality of life scores in the treatment group after treatment were significantly higher than those in the control group (P<0.05). After treatment, the serum sLOX-1, MCP-1, TGF-β1, and ET-1 levels in two groups were significantly decreased, but NO levels were significantly increased, and there were differences in the same group (P<0.05). And these serological indexes in the treatment group after treatment were significantly better than those in the control group (P<0.05). Conclusion Angong Jiangya Pills combined with irbesartan in treatment of primary hypertension has significant clinical effect, can improve the quality of life, which has a certain clinical application value.