目的 探讨百令胶囊联合醋酸泼尼松片治疗狼疮性肾炎的临床疗效。方法 选取2012年6月-2017年8月乐山市市中区人民医院收治的112例狼疮性肾炎患者为研究对象，根据治疗方式的不同将患者分为对照组和治疗组，每组各56例。对照组口服醋酸泼尼松片，1 mg/（kg·d），连续治疗60 d后逐渐将剂量减至10 mg/d。治疗组在对照组的基础上口服百令胶囊，2粒/次，3次/d，两组患者均治疗6个月。观察两组患者的临床疗效，比较治疗前后两组的免疫功能指标、白介素-6（IL-6）、血清胱抑素C（Cys-C）、同型半胱氨酸（Hcy）、血肌酐（Scr）、微量白蛋白尿（mAlb）和系统性狼疮性疾病活动度（SLEDAI）评分。结果 治疗后，对照组和治疗组的总有效率分别为76.79%、91.07%，两组比较差异具有统计学意义（P<0.05）。治疗后两组患者免疫球蛋白A（IgA）、免疫球蛋白M（IgM）和免疫球蛋白G（IgG）水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组免疫功能指标水平显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血清IL-6、Cys-C和Hcy水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组血清IL-6、Cys-C和Hcy水平均显著低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者Scr、mAlb和SLEDAI评分均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；治疗后，治疗组Scr、mAlb和SLEDAI评分显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 百令胶囊联合醋酸泼尼松片治疗狼疮性肾炎具有较好的临床疗效，可改善免疫功能，降低血清IL-6、Cys-C和Hcy水平，且安全性高，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Corbrin Capsules combined with Prednisone Acetate Tablets in treatment of lupus nephritis. Methods Patients (112 cases) with lupus nephritis in the People's Hospital of the Central District of Leshan City from June 2012 to August 2017 were divided into control and treatment groups according to different treatment methods, and each group had 56 cases. Patients in the control group were po administered with Prednisone Acetate Tablets, 1 mg/(kg·d), and the dosage was decreased to 10 mg/d after 60 d of continuous treatment. Patients in the treatment group were po administered with Corbrin Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and immune function indexes, IL-6, Cys-C, Hcy, Scr, mAlb, and SLEDAI scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.79% and 91.07%, respectively, and there was difference between two groups (P < 0.05). After treatment, IgA, IgM, and IgG levels in two groups were significantly decreased, and there were differences in the same group (P < 0.05). After treatment, immune function indexes level in the treatment group were lower than those in the control group, and there were differences between two groups (P < 0.05). After treatment, IL-6, Cys-C, and Hcy levels in two groups were significantly decreased, and there were differences in the same group (P < 0.05). After treatment, IL-6, Cys-C, and Hcy levels in the treatment group were lower than those in the control group, and there were differences between two groups (P < 0.05). After treatment, Scr, mAlb, and SLEDAI scores in two groups were significantly decreased, and there were differences in the same group (P < 0.05). After treatment, Scr, mAlb, and SLEDAI scores in the treatment group were lower than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Corbrin Capsules combined with Prednisone Acetate Tablets has clinical curative effect in treatment of lupus nephritis, can improve immune function, and reduce serum IL-6, Cys-C, and Hcy levels, with good safety, which has a certain clinical application value.