脑缺血再灌注损伤是脑血管疾病主要的病理特征。黄芩苷可通过降低炎症反应，减轻氧化应激反应，抑制神经组织细胞凋亡，减轻缺血性脑水肿，促进神经细胞增殖，调节肠道微生物群，增强孕酮活性降低脑缺血再灌注损伤，对神经功能发挥保护作用。总结了黄芩苷对脑缺血再灌注损伤保护的研究进展，为黄芩苷的临床应用提供循证支持。

Cerebral ischemia-reperfusion injury is the main pathological feature of cerebrovascular diseases. Baicalin can reduce inflammation, alleviate oxidative stress, inhibit neural tissue cell apoptosis, alleviate ischemic brain edema, promote nerve cell proliferation, regulate gut microbiota, enhance progesterone activity, reduce cerebral ischemia-reperfusion injury, and protect neurological function. This article summarizes the research progress on the protection of baicalin against cerebral ischemia-reperfusion injury, providing evidence-based support for the clinical application of baicalin.

R971

河南省科技厅软科学项目（242400410217）