脓毒症肺损伤是脓毒症常见的并发症，是导致死亡的主要原因之一，并且治疗方法仍然非常有限。大黄素具有多种药理作用，可通过降低炎症反应，减轻氧化应激反应，改善肺通透性，降低细胞凋亡，增强水清除率，促进肺自噬多途径、多靶点减轻脓毒症肺损伤。综述了大黄素治疗脓毒症肺损伤的药理作用，总结其作用机制，为大黄素的临床运用提供依据。

Lung injury in sepsis is a common complication of sepsis and one of the main causes of death. The treatment of lung injury in sepsis is still very limited. Emodin has various pharmacological effects, and can reduce inflammation, reduce oxidative stress, improve lung permeability, reduce cell apoptosis, enhance water clearance, promote lung autophagy, and reduce lung injury caused by sepsis through multiple pathways and multiple targets. This article reviews the pharmacological effects of emodin in treatment of lung injury in sepsis, summarizes the mechanism of its therapeutic effect, and provides a basis for the clinical application of emodin.

R974

兰州市科技计划项目（2021-1-103）