吡仑帕奈为第3代新型广谱抗癫痫药物，其血药浓度或药物暴露水平与其临床疗效、不良反应密切相关，因此建议进行治疗药物监测。围绕吡仑帕奈的治疗药物监测开展其有效血药浓度参考范围、血药浓度影响因素研究已成为实现吡仑帕奈个体化精准用药的关键。对吡仑帕奈治疗药物监测的研究报道进行了分析，旨在为吡仑帕奈在临床上的个体化精准用药提供参考。

Perampanel is a third-generation novel broad-spectrum antiepileptic drug, and its blood drug concentration or drug exposure level is closely related to its clinical efficacy and adverse reactions. Therefore, it is recommended to carry on therapeutic drug monitoring. Studies on the reference range of effective blood drug concentration and influencing factors of blood drug concentration have been carried out around the therapeutic drug monitoring for perampanel, which have become the key to realize individualized precise use of perampanel. This article analyzes the research reports on the therapeutic drug monitoring for perampanel, aiming to provide reference for individualized precision use of perampanel in clinical practice.

R971

安徽省药师协会药师队伍建设“扶持计划”治疗药物监测与个体化用药研究专项（SPSG2023001004）；安徽医科大学校科研基金项目（2022xkj100）；六安市科技计划项目（2022lakj005）