乳腺癌在全球范围内女性恶性肿瘤发病率排名首位。化学药物能杀灭肿瘤细胞、降低癌灶转移复发、提高患者的生存率，但其产生的不良反应、耐药性也制约了患者用药疗效和适用范围。β-榄香烯是从郁金中提取的倍半萜类化合物，可通过抑制肿瘤细胞生长和增殖、诱导肿瘤细胞凋亡、抑制肿瘤细胞侵袭和转移、逆转肿瘤药物耐药、协同化疗增强疗效、协同放疗增敏等作用机制治疗乳腺癌，同时在临床上通过调节机体免疫功能减轻不良反应、联合靶向药物增强临床疗效、抑制癌细胞转移降低并发症发生风险治疗乳腺癌。综述了β-榄香烯治疗乳腺癌的作用机制和临床应用的研究进展，以期为β-榄香烯治疗乳腺癌提供参考。

Breast cancer ranks first in the incidence rate among all female malignant tumors worldwide. Chemical drugs can kill tumor cells, reduce cancer metastasis and recurrence, and improve patient survival rates, but their adverse reactions and drug resistance also limit the efficacy and applicability of medication for patients. β-Elemene is a sesquiterpene compound extracted from Curcumae Radix, and can treat breast cancer by inhibiting tumor cell growth and proliferation, inducing tumor cell apoptosis, inhibiting tumor cell invasion and metastasis, reversing tumor drug resistance, cooperating with chemotherapy to enhance efficacy, cooperating with radiotherapy to sensitization and other mechanisms. At the same time, it can reduce adverse reactions by regulating the immune function of the body, combining targeted drugs to enhance clinical efficacy, and inhibiting cancer cell metastasis to reduce the risk of complications in clinical treatment of breast cancer. This article reviews the research progress on the mechanism and clinical application of β-elemene in treatment of breast cancer, in order to provide reference for β-elemene in treatment of breast cancer.

R979.1

吴阶平医学基金会临床科研专项（HK8203521）