神经系统疾病是目前世界范围内的主流高发性疾病，有较高的致残率和死亡率，形成原因多样，临床表型繁多，发病机制复杂，目前适用药物仍无法对疾病的发展起到完全治疗作用。迷迭香酸是一种多酚羟基化合物，可通过发挥抗氧化活性、改善突触功能和缓解神经炎症防治脑缺血、抑郁症、阿尔茨海默病、帕金森病、脊髓损伤等神经系统疾病。综述了迷迭香酸治疗神经系统疾病及其作用机制的研究进展，为防治神经系统疾病的药物研发和临床应用提供参考。

Nervous system diseases are currently the mainstream and highly prevalent diseases worldwide, with high disability and mortality rates, diverse causes, numerous clinical phenotypes, and complex pathogenesis. Currently, drugs still cannot fully treat the development of diseases. Rosmarinic acid is a polyphenolic hydroxy compound that can prevent and treat nervous system diseases such as cerebral ischemia, depression, Alzheimer's disease, Parkinson's disease, and spinal cord injury by exerting antioxidant activity, improving synaptic function, and alleviating neuroinflammation. This article reviews the research progress of rosmarinic acid in treatment of nervous system diseases and their mechanisms, providing reference for drug development and clinical application in prevention and treatment of nervous system diseases.

R971

福建省自然科学基金项目（2024J01129）；福建中医药大学基础类学科科研提升计划项目（XJC2022016）