目的 探讨金凤丸联合注射用绒促性素治疗子宫内膜薄型不孕症患者的临床疗效。方法 选取2022年4月—2023年4月在南阳市中心医院确诊并规范治疗的110例子宫内膜薄型不孕症患者作为研究对象，依据随机数字表法分成治疗组和对照组，每组各55例。对照组患者采用注射用绒促性素肌内注射治疗，4 000 U/次，3 d/次；治疗组在对照组用药基础上加用金凤丸口服治疗，10丸/次，2次/d。两组均接受为期3个月的连续治疗。对比两组患者的妊娠情况、子宫内膜厚度、子宫内膜容积、月经症状量表中文版（MDQ）评分，子宫内膜搏动指数（PI）、血流阻力指数（RI）和收缩期峰值流速/舒张末期流速（S/D）水平。结果 治疗后，治疗组HCG阳性率、临床妊娠率和活产率分别为63.64%、50.91%、82.14%，对照组HCG阳性率、临床妊娠率和活产率分别为40.00%、30.91%、52.94%，治疗组均明显高于对照组（P＜0.05）。治疗后，治疗组子宫内膜薄型不孕症患者子宫内膜厚度、子宫内膜容积均显著增加，而MDQ评分显著降低（P＜0.05）；治疗后，治疗组子宫内膜厚度、子宫内膜容积大于对照组，MDQ评分低于对照组（P＜0.05）。治疗后，治疗组子宫内膜薄型不孕症患者PI、RI和S/D均明显降低（P＜0.05）；治疗后，治疗组PI、RI和S/D明显低于对照组（P＜0.05）。结论 金凤丸联合注射用绒促性素治疗子宫内膜薄型不孕症患者疗效显著，不仅能够显著提升患者妊娠率和活产率，而且还能够改善患者子宫内膜容受性和血流指数，值得进行深入研究并加以推广。

Objective To explore the clinical efficacy of Jinfeng Pills combined with chorionic gonadotrophin in treatment of endometrial thin infertility. Methods A total of 110 cases of patients with thin endometrial infertility diagnosed and standardized treatment in Nanyang Central Hospital from April 2022 to April 2023 were selected as research objects, and were divided into treatment group and control group according to random number table method, with 55 cases in each group. Patients in control group were im administered with Chorionic Gonadotrophin for Injection, 4 000 U/time, 3 d/time. Patients in the treatment group were po administered with Jinfeng Pills on the basis of control group, 10 pills/time, twice daily. Both groups received continuous treatment for 3 months. The pregnancy status, endometrial thickness, endometrial volume, MDQ score, endometrial PI, RI, and peak systolic flow velocity/end-diastolic flow velocity (S/D) levels of the two groups were compared. Results After treatment, the HCG positive rate, clinical pregnancy rate and live birth rate in the treatment group were 63.64%, 50.91%, and 82.14%, respectively, while the HCG positive rate, clinical pregnancy rate and live birth rate in the control group were 40.00%, 30.91%, and 52.94%, respectively, which were significantly higher in the treatment group than in the control group (P < 0.05). After treatment, endometrial thickness and endometrial volume of patients with thin endometrial infertility in the treatment group were significantly increased, but MDQ score was significantly decreased (P < 0.05). After treatment, the endometrial thickness and endometrial volume of the treatment group were higher than that of the control group, but the MDQ score was lower than that of the control group (P < 0.05). After treatment, PI, RI and S/D of patients with endometrial thin infertility in the treatment group were significantly decreased (P < 0.05). After treatment, PI, RI and S/D in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Jinfeng Pills combined with chorionic gonadotrophin has significant curative effect on patients with endometrial thin infertility, and can not only significantly improve the pregnancy rate and live birth rate of patients, but also improve the endometrial tolerance and blood flow index of patients, which is worthy of further study and promotion.

R984

河南省医学科技攻关省部共建青年项目（SBGJ202103107）