目的 探讨芪血颗粒联合复方硫酸亚铁颗粒治疗妊娠期缺铁性贫血的临床疗效。方法 选取2022年3月—2024年10月在邢台市中心医院就诊的妊娠期贫血患者共90例，按随机数字表法分为对照组和治疗组，每组45例。对照组开水冲服复方硫酸亚铁颗粒，1袋/次，1次/d。治疗组在对照组的基础上开水冲服芪血颗粒，1袋/次，3次/d。两组持续治疗2个月。比较两组的临床疗效、症状消失时间、红细胞指标、铁代谢指标。结果 对照组的总有效率为82.22%，明显低于治疗组的总有效率95.56%，组间差异显著（P＜0.05）。治疗组患者的虚弱、头晕头痛、手脚冰凉、呼吸急促消失时间均短于对照组（P＜0.05）。治疗后，两组的红细胞计数、红细胞平均血红蛋白、平均红细胞体积明显升高（P＜0.05），且治疗组的红细胞计数、红细胞平均血红蛋白、平均红细胞体积明显高于对照组（P＜0.05）。治疗后，两组的铁蛋白升高，可溶性转铁蛋白受体、不饱和铁结合力降低（P＜0.05）；治疗组患者的铁蛋白高于对照组，可溶性转铁蛋白受体、不饱和铁结合力低于对照组（P＜0.05）。结论 芪血颗粒联合复方硫酸亚铁颗粒可提高妊娠期贫血的临床疗效，促进症状改善，改善红细胞参数和铁代谢。

Objective To explore the clinical efficacy of Qixue Granules combined with Compound Ferrous Sulfate Granules in treatment of anemia in pregnancy. Methods 90 Patients with anemia in pregnancy who visited Xingtai Central Hospital from March 2022 to October 2024 were selected and were divided into control group and treatment group using a random number table method, with 45 cases in each group. Patients in the control group took Compound Ferrous Sulfate Granules with boiled water, 1 bag/time, once daily. On the basis of the control group, patients in the treatment group took Qixue Granules with boiled water, 1 bag/time, 3 times daily. Two groups received 2 months of continuous treatment. The clinical efficacy, symptom disappearance time, red blood cell indicators, and iron metabolism indicators were compared between two groups. Results The total effective rate of patients in the control group was 82.22%, that in the treatment group was 95.56%, and the difference between two groups was significant (P < 0.05). The disappearance time of weakness, dizziness, headache, cold hands and feet, and shortness of breath in the treatment group was shorter than that in the control group (P < 0.05). The red blood cell count, average red blood cell hemoglobin, and average red blood cell volume of the two groups were significantly increased after treatment (P < 0.05), and red blood cell count, average red blood cell hemoglobin, and average red blood cell volume in the treatment group were higher than those in the control group (P < 0.05). After treatment, ferritin levels in both groups were increased, but the soluble transferrin receptor and unsaturated iron binding capacity were decreased (P < 0.05). The ferritin levels in the treatment group were higher than those in the control group, but the soluble transferrin receptor and unsaturated iron binding capacity were lower than those in the control group (P < 0.05). Conclusion Qixue Granules combined with Compound Ferrous Sulfate Granules can improve the efficacy of pregnancy anemia, promote symptom improvement efficiency, improve red blood cell parameters and iron metabolism.

R984

邢台市重点研发计划自筹项目（2023ZC065）