目的 观察槐榆清热止血胶囊联合地奥司明治疗混合痔的临床疗效。方法 回顾性研究2022年6月—2023年7月重庆两江新区人民医院收治的100例混合痔患者，随机数字法分为对照组和治疗组，每组50例。对照组口服地奥司明片，1片/次，每日2次。在对照组的基础上，治疗组口服槐榆清热止血胶囊，3粒/次，每日3次。两组治疗15 d观察效果。对比两组的疗效，比较治疗前后两组患者术后创面康复时间、中性粒细胞-淋巴细胞比值（NLR）、视觉模拟疼痛评分（VAS）、白细胞计数（WBC）、C反应蛋白（CRP）、中性粒细胞百分比（N%）。结果 治疗后，治疗组有效率为98.00%高于对照组82.00%（P＜0.05）。治疗后，与对照组对比，治疗组术后的愈合时间、分泌消失时间、水肿消失时间、出血消失时间均较早（P＜0.05）。治疗后，与对照组对比，治疗组术后4、7 d疼痛评分均较低（P＜0.05）。治疗后，两组WBC、N%、NLR、CRP水平比治疗前明显降低（P＜0.05），且治疗后，与对照组比较，治疗组WBC、N%、NLR、CRP水平下降更显著（P＜0.05）。结论 槐榆清热止血胶囊与地奥司明协同治疗，可促进创面水肿消退，减少术后创面出血，促使创面愈合时间缩短，有效降低术后疼痛及炎性反应。

Objective To explore the clinical efficacy of t Huaiyu Qingre Zhixue Capsules combined with diosimin in treatment of mixed hemorrhoids. Methods The clinical data of patients (100 cases) with mixed hemorrhoids in People's Hospital of Chongqing Liangjiang New Area from June 2022 to July 2023 were analyzed retrospectively. They were divided into control (50 cases) and treatment (50 cases) group by random number method. Patients in the control group were po administered with Diosmin Tables, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Huaiyu Qingre Zhixue Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 15 d. After treatment, the clinical evaluations were evaluated, the postoperative wound rehabilitation time, VAS scores, and the inflammatory factors WBC, N%, NLR and CRP levels in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group was 98.00%, which was significantly higher than that in the control group (82.00%, P < 0.05). After treatment, the postoperative wound healing time, wound edema time, wound secretion time, and wound bleeding time in the treatment group were earlier than those in the control group (P < 0.05). After treatment, the pain scores in the treatment group at 4 and 7 days after surgery were significantly lower than those in the control group (P < 0.05). After treatment, the levels of WBC, N%, NLR, and CRP in two groups were significantly lower than those before treatment (P < 0.05). After treatment, compared with the control group, the levels of WBC, N%, NLR, and CRP in the treatment group were decreased more significantly (P < 0.05). Conclusion The synergistic treatment of Huaiyu Qingre Zhixue Capsules and diosmin can promote the subsidence of traumatic edema, reduce postoperative traumatic hemorrhage, prompt the shortening of traumatic healing time, effectively reduce the postoperative pain and inflammatory reaction.

R982

重庆市科卫联合医学科研项目（2022MSXM110）