目的 探讨肺力咳合剂联合阿奇霉素治疗儿童百日咳的临床疗效。方法 选取2024年1月—2024年8月河南科技大学第一附属医院收治的80例百日咳患儿，按随机数字表法分为对照组和治疗组，每组各40例。对照组口服阿奇霉素颗粒，第1天10 mg/kg，第2～5天5 mg/kg，顿服，用药5 d后停2 d。治疗组在此基础上口服肺力咳合剂，4岁≤年龄≤7岁者，10 mL/次，7岁＜年龄≤12岁者，15 mL/次，均3次/d。两组疗程7 d。观察两组的临床疗效，比较两组痉挛性咳嗽缓解时间、鼻咽部细菌清除率及治疗前后咳嗽症状评分、儿童睡眠习惯问卷（CSHQ）评分和血常规指标[白细胞数（WBC）、淋巴细胞比率（LYMPH%）]。结果 治疗组总有效率是95.00%，显著高于对照组的80.00%（P＜0.05）。治疗组痉挛性咳嗽缓解时间显著短于对照组，鼻咽部细菌清除例数和清除率显著高于对照组（P＜0.05）。治疗后，两组咳嗽症状日间评分、夜间评分及总分均显著减少（P＜0.05）；治疗后，治疗组咳嗽症状评分低于对照组（P＜0.05）。治疗后两组CSHQ评分和WBC、LYMPH%都低于同组治疗前（P＜0.05）；治疗后，治疗组CSHQ评分和WBC、LYMPH%低于对照组（P＜0.05）。结论 针对儿童百日咳采取肺力咳合剂联合阿奇霉素治疗，患儿耐受性较好，能有效控制感染和减轻咳嗽症状，改善患儿睡眠状况，促进病情改善。

Objective To investigate the clinical efficacy of Feilike Mixture combined with azithromycin in treatment of children with pertussis. Methods A total of 80 children with pertussis treated in The First Affiliated Hospital of Henan University of Science and Technology from January 2024 to August 2024 were randomly divided into control group and treatment group according to random number table method, 40 cases in each group. Patients in control group were po administered with Azithromycin Granules, 10 mg/kg on the first day, 5 mg/kg on the second to fifth day, after 5 d of medication, stopped for 2 d. Patients in treatment group were po administered with Feilike Mixture on basis of control group, 10 mL/ time for those aged 4 years ≤ 7 years old and 15 mL/time for those aged 7 years < 12 years old, 3 times daily. Both groups were treated for 7 d. The clinical efficacy of two groups were observed, and the remission time of spastic cough, nasopharyngeal bacterial clearance rate, cough symptom score, children's sleep habits questionnaire (CSHQ) score and blood routine indexes (WBC, LYMPH%) before and after treatment were compared between two groups. Results The total effective rate of treatment group was 95.00%, which was significantly higher than that of control group (80.00%, P < 0.05). The remission time of spastic cough in treatment group was significantly shorter than that in control group, and the number and clearance rate of nasopharyngeal bacteria were significantly higher than that in control group (P < 0.05). After treatment, daytime scores, nighttime scores and total scores of cough symptoms were significantly decreased in both groups (P < 0.05). After treatment, the cough symptom score of treatment group was lower than that of control group (P < 0.05). After treatment, the CSHQ score, WBC, LYMPH% in both groups were lower than before (P < 0.05). After treatment, CSHQ score, WBC, and LYMPH% in treatment group were lower than those in control group (P < 0.05). Conclusion The combination of Feilike Mixture and azithromycin for pertussis in children can effectively control infection, and can relieve cough symptoms, improve sleep conditions, which can promote improvement of disease.

R974