目的 探讨丹黄祛瘀胶囊联合盐酸多西环素片治疗慢性盆腔炎的临床疗效。方法 分析2021年1月—2024年1月在无锡市妇幼保健院接受治疗的105例慢性盆腔炎患者病例资料，根据用药方案分为对照组（52例）和治疗组（53例）。对照组口服盐酸多西环素片，1片/次，2次/d；治疗组在对照组基础上口服丹黄祛瘀胶囊，2粒/次，3次/d。两组均持续治疗2周。比较两组患者的临床疗效、临床症状消失时间、血液流变学和血清炎症指标。结果 治疗组的总有效率为94.34%，对照组的总有效率为78.85%，组间比较差异显著（P<0.05）。治疗组下腹疼痛、腰骶胀痛、带下异常消失时间均短于对照组（P<0.05）。治疗后，两组血浆黏度（PV）、红细胞比容（HCT）、红细胞沉降率（ESR）和血清C反应蛋白（CRP）、白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)水平均降低（P<0.05），且治疗组PV、HCT、ESR和血清CRP、IL-1β、IL-8水平明显低于对照组（P<0.05）。结论 慢性盆腔炎患者在盐酸多西环素片治疗的基础上加用丹黄祛瘀胶囊可提高临床疗效，改善血液流变学，降低血清炎症指标水平。

Objective To investigate the clinical efficacy of Danhuang Quyu Capsules combined with Doxycycline Hydrochloride Tablets in treatment of chronic pelvic inflammatory disease. Methods The case data of 105 patients with chronic pelvic inflammatory disease treated in Wuxi Maternal and Child Health Hospital from January 2021 to January 2024 were analyzed, and were divide into control group（52 cases） and treatment group（53 cases） according to the medication scheme. The control group took oral Doxycycline Hydrochloride Tablets, 1 tablets/time, twice daily. The treatment group took Danhuang Quyu Capsules orally on the basis of the control group, 2 capsules/time, 3 times daily. Both groups were treated for 2 weeks. The clinical efficacy, disappearance time of clinical symptoms, hemorheology, and serum inflammatory indicators were compared between two groups. Results The total effective rate of the treatment group was 94.34%, the total effective rate of the control group was 78.85%, and the difference between the groups was significant（P＜0.05）. The disappearance times of lower abdominal pain, lumbosacral distension pain, and abnormal vaginal discharge in the treatment group were shorter than those in the control group（P＜0.05）. After treatment, PV, HCT, ESR, and serum CRP, IL-1β, and IL-8 levels in both groups were decreased（P＜0.05）, and PV, HCT, ESR, serum CRP, IL-1β, and IL-8 levels in the treatment group were significantly lower than those in the control group（P＜0.05）. Conclusion Danhuang Quyu Capsules combined with Doxycycline Hydrochloride Tablets can improve clinical efficacy in treatment of chronic pelvic inflammatory disease, improve hemorheology, and reduce serum inflammatory index levels.

R984

江苏省妇幼健康科研项目(F202107)