目的 优化荆芥穗挥发油β-环糊精包合物的高速剪切包合工艺。方法 在单因素考察的基础上，以包合物收率、胡薄荷酮包合率的综合评分为评价指标，以β-环糊精与挥发油倍量比、剪切转速和剪切包合时间为考察因素，采用Box-Behnken响应面法进行包合工艺优化，通过Design-Expert 13软件分析各因素的交互作用优选最佳工艺条件。结果 采用高速剪切法制备荆芥穗挥发油β-环糊精包合物的最佳工艺参数为β-环糊精与挥发油倍量比为8∶1，β-环糊精与纯化水倍量比1∶8，剪切包合时间40 min，剪切转速为7 700 r/min。结论 优化后的工艺包合率和收率较高，工艺合理可行，对后续产品的研究和生产具有一定指导作用。

Objective To optimize the high-speed shear inclusion process on Schizonepetae Spica volatile oil - β-cyclodextrin inclusion complex. Methods On the basis of single factor test, the inclusion process was optimized by Box-Behnken response surface method with the comprehensive score of inclusion complex yield and pulegone inclusion rate as the evaluation index, and mass ratio of β-cyclodextrin to volatile oil, shear speed, and shear time as the investigation factors. The optimum process conditions were selected by analyzing the interaction of various factors by Design-Expert 13 software. Results The optimum process parameters of preparing Schizonepetae Spica volatile oil - β-cyclodextrin inclusion complex by high-speed shearing method were as following: the ratio of β-cyclodextrin to volatile oil was 8∶1, the mass ratio of β-cyclodextrin to purified water was 1∶8, the shearing inclusion time was 40 min, and the shearing speed was 7 700 r/min. Conclusion The optimized process has high inclusion rate and inclusion yield, and the process is reasonable and feasible, which has a certain guiding role for the research and production of subsequent products.

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云南省重大科技专项计划（202102AA310027）；云南省科技人才与平台计划（202105AG070014）；石家庄市产业技术研究院建设任务（228790779A）