急性胰腺炎具有发病迅速、并发症多、死亡率高等特点。川芎嗪可通过促进细胞凋亡、纠正微循环障碍、减轻炎症反应、减轻脂质过氧化反应、抑制脂多糖/Toll样受体4信号通路、保护小肠黏膜屏障功能发挥防治急性胰腺炎的作用。归纳了川芎嗪防治急性胰腺炎的作用机制，为急性胰腺炎的治疗提供参考。

Acute pancreatitis is characterized by fatal, pathogenic and high mortality. Ligustrazine can play a role in prevention and treatment of acute pancreatitis by promoting cell apoptosis, correcting microcirculation disorders, alleviating inflammatory reactions, reducing lipid peroxidation, inhibiting LPS/TLR4 signaling pathways, and protecting the intestinal mucosal barrier function. This article summarizes the mechanism of ligustrazine in prevention and treatment of acute pancreatitis, providing reference for the treatment of acute pancreatitis.

R285;R975

重庆市大足区科技发展项目（DZKJ-2021ACC1014）