卵巢癌是第2大普遍存在的妇科恶性肿瘤，具有较高的死亡率。化疗是卵巢癌主要的治疗手段，但大多数患者会发生化疗耐药性。雷公藤甲素是从雷公藤中提取的天然活性二萜类化合物，具有多种药理活性。雷公藤甲素可以通过抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、降低卵巢癌侵袭力、降低卵巢癌对顺铂耐药性、调节卵巢癌细胞周期、增强抗肿瘤免疫应答、改变肿瘤微环境发挥多途径防治卵巢癌。归纳了雷公藤甲素防治卵巢癌的作用机制，为卵巢癌的临床治疗提供依据。

Ovarian cancer is the second most common gynecological malignancy with a high mortality rate. Chemotherapy is the main treatment for ovarian cancer, but most patients will develop chemotherapy resistance. Tripterygiolide is a naturally active diterpenoid compound extracted from Tripterygii Wilfordii Radix et Rhizoma, with various pharmacological activities. Triptolide can play a multiple pathways to prevent and treat ovarian cancer by inhibiting tumor cell proliferation, promoting cell apoptosis, reducing invasiveness of ovarian cancer, reducing tumor cell resistance against cisplatin, regulating ovarian cancer cell cycle, enhancing anti-tumor immune response, and altering the tumor microenvironment. This article summarizes the mechanism of triptolide in prevention and treatment of ovarian cancer, providing a basis for the clinical treatment for ovarian cancer.

R285;R984

河北省卫生和计划生育委员会科研项目（20171027）