目的 探讨复方珍珠口疮颗粒联合康复新液治疗口腔溃疡的临床疗效。方法 选取2020年7月—2023年6月上海市嘉定区安亭医院收治的96例口腔溃疡患者，按随机数字表法分为对照组和治疗组，每组各48例。对照组含漱康复新液10 mL/次，每次含漱5 min，3次/d，用药后30 min内避免漱口、禁饮禁食。治疗组在对照组治疗基础上口服复方珍珠口疮颗粒，1袋/次，2次/d，饭后30 min以100 mL开水溶解后分次口含，每次口含1～2 min后缓慢咽下，10 min内用完。两组疗程均为1周。观察两组的临床疗效、疼痛缓解和溃疡面愈合时间。比较治疗前后两组疼痛视觉模拟量表（VAS）评分、14项口腔健康影响程度量表（OHIP-14）评分、症状自评量表（SCL-90）评分及血清白细胞介素-17（IL-17）、补体C3和C4、超氧化物歧化酶（SOD）和转化生长因子-β（TGF-β）水平。结果 治疗后，治疗组总有效率是97.92%，较对照组的83.33%显著提高（P＜0.05）。经治疗，治疗组疼痛缓解时间和溃疡面愈合时间均显著短于对照组（P＜0.05）。治疗后，两组疼痛VAS、OHIP-14和SCL-90评分均显著降低（P＜0.05）；且治疗后，治疗组VAS、OHIP-14和SCL-90评分低于对照组（P＜0.05）。治疗后，两组血清IL-17水平均显著降低，而血清补体C3、C4和SOD、TGF-β水平均显著增高（P＜0.05）；且治疗后，治疗组血清IL-17、补体C3、补体C4、SOD和TGF-β水平改善优于对照组（P＜0.05）。结论 复方珍珠口疮颗粒联合康复新液治疗口腔溃疡效果较好，能有效促进患者疼痛减轻和溃疡面愈合，调节免疫紊乱及炎症反应，对患者病情恢复、心理状态及生活质量的改善效果明显，值得临床推广应用。

Objective To investigate the clinical efficacy of Compound Zhenzhu Kouchuang Granules combined with Kangfuxin Liquid in treatment of oral ulcer. Methods A total of 96 patients with oral ulcer admitted to Anting Hospital of Jiading District in Shanghai from July 2020 to June 2023 were selected and divided into control group and treatment group according to random number table method, with 48 cases in each group. Patients in the control group were given Kangfuxin Liquid, 10 mL/time with gargling for 5 min each time, three times daily. Avoid gargling, drinking and fasting within 30 min after medication. Patients in the treatment group were given Compound Zhenzhu Kouchuang Granules on the basis of the control group, 1 bag/time, twice daily, dissolved in 100 mL boiling water 30 min after meal, swallowed slowly after 1-2 minutes each time, and used up within 10 min. The treatment course of both groups was 1 week. The efficacy, pain relief, and ulcer healing time were observed. The visual analogue scale (VAS) for pain, 14-item Oral Health Impact Profile (OHIP-14), Symptom Checklist-90 (SCL-90) scores, and serum interleukin-17 (IL-17), complement C3, C4, superoxide dismutase (SOD), and transforming growth factor-beta (TGF-β) levels were compared in two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 97.92%, which was significantly higher than that of control group (83.33%) (P < 0.05). After treatment, the pain relief time and ulcer healing time in treatment group were significantly shorter than those in control group (P < 0.05). After treatment, pain VAS, OHIP-14, and SCL-90 scores were significantly decreased in both groups (P < 0.05). After treatment, VAS, OHIP-14, and SCL-90 scores in the treatment group were lower than those in control group (P < 0.05). After treatment, serum IL-17 levels were significantly decreased in both groups, but serum complement C3, C4, SOD, TGF-β levels were significantly increased (P < 0.05). After treatment, the levels of IL-17, complement C3, complement C4, SOD and TGF-β in treatment group were better than those in control group (P < 0.05). Conclusion Compound Zhenzhu Kouchuang Granules combined with Kangfuxin Liquid has a good effect in treatment of oral ulcer, and can effectively promote patients' pain relief and ulcer surface healing, regulate immune disorders and inflammatory response, and improve patients' condition recovery, psychological state and life quality, which is worthy of clinical application.

R988.2