目的 探讨复方鹿茸健骨胶囊联合唑来膦酸注射液治疗骨质疏松症的临床疗效。方法 选取唐山市人民医院2020年8月—2023年2月收治的132例骨质疏松症患者，根据计算机随机排列法将患者分为对照组和治疗组，各66例。对照组患者静脉滴注唑来膦酸注射液，1支/次，1次/4周。治疗组在对照组基础上口服复方鹿茸健骨胶囊，5粒/次，3次/d。两组患者连续治疗6个月。比较两组的临床疗效、疼痛程度、骨密度、血清骨代谢指标和血清炎症反应指标。结果 治疗后，治疗组的总有效率（92.42%）比对照组高（80.30%），组间差异显著（P＜0.05）。治疗后，两组的数字疼痛强度量表（NRS）评分均低于治疗前（P＜0.05），且治疗组的NRS评分低于对照组（P＜0.05）。治疗后，两组粗隆、股骨颈、腰椎的骨密度比治疗前大（P＜0.05），且治疗组粗隆、股骨颈、腰椎的骨密度比对照组更大（P＜0.05）。治疗后，两组的血清骨钙素（BGP）、基质金属蛋白酶-9（MMP-9）、白细胞介素-17（IL-17）水平显著降低，血清骨特异性碱性磷酸酶（BALP）、骨保护素（OPG）水平显著升高（P＜0.05）；治疗组的血清BGP、MMP-9、IL-17水平低于对照组，血清BALP、OPG水平高于对照组（P＜0.05）。结论 复方鹿茸健骨胶囊联合唑来膦酸注射液可显著提高骨质疏松症的疗效，进一步提高骨密度，调节骨代谢水平，降低炎症反应。

Objective To investigate the clinical effect of Compound Lurong Jiangu Capsules combined with Zoledronic Acid Injection in treatment of osteoporosis. Methods Patients (132 cases) with osteoporosis in Tangshan People's Hospital from August 2020 to February 2023 were divided into control and treatment groups according to the computer random arrangement method, and each group had 66 cases. Patients in the control group were iv administered with Zoledronic Acid Injection, 1 dose/time, once every 4 weeks. Patients in the treatment group were po administered with Compound Lurong Jiangu Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 6 months. The clinical efficacies, pain level, bone density, serum bone metabolism indicators, and serum inflammatory response indicators in two groups were compared. Results After treatment, the total effective rate of the treatment group (92.42%) was higher than that of the control group (80.30%), and the difference between groups was significant (P < 0.05). After treatment, NRS score of two groups was lower than before treatment (P < 0.05), and NRS score of the treatment group was lower than that of the control group (P < 0.05). After treatment, the bone density of trochanter, femoral neck, and lumbar spine in both groups was higher than that before treatment (P < 0.05), and the bone density of trochanter, femoral neck, and lumbar spine in treatment group was higher than that in control group (P < 0.05). After treatment, the levels of BGP, MMP-9, and IL-17 were lower than before treatment, but the levels of BALP and OPG were higher than before treatment (P < 0.05). After treatment, the levels of BGP, MMP-9, and IL-17 in the treatment group was lower than that in the control group, but the levels of BALP and OPG were higher than those in the control group (P < 0.05). Conclusion Compound Lurong Jiangu Capsules combined with Zoledronic Acid Injection can significantly improve the curative effect of osteoporosis, further improve bone density, regulate bone metabolism and reduce inflammation.

R982

河北省卫生健康委科研基金项目（20211110）