目的 探讨小儿定喘口服液联合硫酸沙丁胺醇治疗小儿轻中度支气管哮喘的临床疗效。方法 选取2022年7月—2023年7月河南省儿童医院收治的轻中度支气管哮喘患儿90例，随机分为对照组（45例）和治疗组（45例）。对照组患者雾化吸入硫酸沙丁胺醇吸入气雾剂，100 µg/次，1次/6 h。治疗组在对照组的基础上口服小儿定喘口服液，10 mL/次，3次/d。两组连服药7 d。观察两组患者临床疗效，比较治疗前后两组患者症状改善时间，血清超氧化物歧化酶（SOD）、内皮素（ET）、一氧化氮（NO）、白细胞介素-6（IL-6）、干扰素-γ（INF-γ）、降钙素原（PCT）和血白三烯C4（LTC4）水平，及不良反应情况。结果 治疗后，治疗组患者临床总有效率为97.78%，明显高于对照组（82.22%，P＜0.05）。治疗后，治疗组症状改善时间明显早于对照组（P＜0.05）。治疗后，两组SOD和INF-γ水平明显升高，而ET、NO、IL-6、PCT、LTC4水平明显降低（P＜0.05），且治疗组这些指标水平明显好于对照组（P＜0.05）。治疗组不良反应发生率（6.67%）明显低于对照组（20.00%）（P＜0.05）。结论 硫酸沙丁胺醇联合小儿定喘口服液治疗小儿轻中度支气管哮喘，可有效改善氧化应激反应，并减弱支气管炎性反应。

Objective To explore the clinical effect of Xiao'er Dingchuan Oral Liquid combined with salbutamol sulfate in treatment of mild to moderate bronchial asthma in children. Methods Children (90 cases) with mild to moderate bronchial asthma in Henan Children's Hospital from July 2022 to July 2023 were randomly divided into control (45 cases) and treatment (45 cases) group. Children in the control group were administered with Salbutamol Sulfate Inhalation Aerosol, 100 µg/time, once every 6 h. Children in the treatment group were po administered with Xiao'er Dingchuan Oral Liquid on the basis of the control group, 10 mL/time, three time daily. Children in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, the levels of serum SOD, ET, NO, IL-6, PCT, LTC4 and INF-γ, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.78%, which was significantly higher than that of the control group (82.22%, P < 0.05). After treatment, the time of symptom improvement in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the levels of SOD and INF-γ were significantly increased, while the levels of ET, NO, IL-6, PCT and LTC4 were significantly decreased in two groups (P < 0.05), and these indexes in the treatment group were significantly better than those in the control group (P < 0.05). The incidence of adverse reactions in the treatment group (6.67%) was significantly lower than that in the control group (19.78%) (P < 0.05). Conclusion Xiao'er Dingchuan Oral Liquid combined with salbutamol sulfate in treatment of mild to moderate bronchial asthma in children can effectively improve the oxidative stress response and reduce the bronchial inflammatory response.

R974

河南省医学科技攻关计划联合共建项目（LHGJ20210647）