目的 探讨地奥心血康胶囊联合阿托伐他汀治疗稳定型心绞痛的疗效。方法 选取2021年3月—2023年3月在芜湖市第一人民医院治疗的稳定型心绞痛患者136例，采用随机数表法将136例患者分为对照组（68例）和治疗组（68例）。对照组口服阿托伐他汀钙片，20 mg/次，1次/d。治疗组在对照组基础上口服地奥心血康胶囊，2粒/次，3次/d。所有患者均治疗4周。观察两组患者临床疗效，比较治疗前后两组患者中医症状积分、总胆固醇、低密度脂蛋白胆固醇（LDL-C）、非高密度脂蛋白胆固醇（non-HDL-C）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）水平。结果 治疗后，对照组总有效率为80.88%，明显低于治疗组（92.65%，P＜0.05）。治疗后，两组气短、胸痛、心悸、胸闷积分显著降低（P＜0.05），且治疗组中医症状积分低于对照组（P＜0.05）。治疗后，两组总胆固醇、LDL-C、non-HDL-C、CRP、TNF-α、IL-1β水平明显低于治疗前（P＜0.05），且治疗组的降低幅度大于对照组（P＜0.05）。结论 地奥心血康胶囊联合阿托伐他汀治疗稳定型心绞痛安全有效，可显著改善患者的血脂水平和炎症状态，是临床治疗稳定型心绞痛的有效方案。

Objective To explore the efficacy of Di'ao Xinxuekang Capsules combined with atorvastatin in treatment of stable angina pectoris. Methods Patients (136 cases) with stable angina pectoris in the First People's Hospital of Wuhu from March 2021 to March 2023 were divided into control (68 cases) and treatment (68 cases) group by random number table method. Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the treatment group were po administered with Di'ao Xinxuekang Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluations were evaluated, the levels of TCM symptom scores, total cholesterol, LDL-C, non-HDL-C, CRP, TNF-α and IL-1β in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the control group was 80.88%, which was significantly lower than that of the treatment group (92.65%, P < 0.05). After treatment, the scores of shortness of breath, chest pain, palpitation and chest tightness in the two groups were significantly decreased (P < 0.05), and the scores of TCM symptoms in the treatment group were lower than those in the control group (P < 0.05). After treatment, the levels of total cholesterol, LDL-C, non-HDL-C, CRP, TNF-α and IL-1β in two groups were significantly lower than those before treatment (P < 0.05), and the decrease in the treatment group was higher than that in the control group (P < 0.05). Conclusion The combination of Di'ao Xinxuekang Capsules combined with atorvastatin is safe and effective in treatment of stable angina pectoris, which can significantly improve the patient's blood lipid levels and inflammatory status, which is an effective clinical treatment for stable angina pectoris.

R972

安徽省重点研究与开发计划项目（2022e07020058）