目的 探讨红金消结胶囊联合左炔诺孕酮宫内缓释系统治疗子宫肌瘤的临床疗效。方法 选取郑州市第七人民医院2021年7月至2023年1月收治的96例子宫肌瘤患者作为研究对象，按随机抽签法分为对照组和治疗组，各48例。对照组采用左炔诺孕酮宫内释放系统，于月经后3～5 d刮除大部分内膜后放置左炔诺孕酮宫内节育系统，疗程为3个月。治疗组在对照组基础上口服红金消结胶囊，4粒/次，3次/d。两组连续治疗3个月。比较两组的临床疗效、月经出血量、子宫体积、肌瘤体积、生活质量、血清性激素水平。结果 治疗后，治疗组的总有效率较对照组高（P＜0.05）。治疗后，两组月经出血量、子宫体积、肌瘤体积以及血清促黄体生成素（LH）、卵泡刺激素（FSH）、孕酮（P）、雌二醇（E₂）水平均低于治疗前，物质生活状态评分、躯体功能评分、心理功能评分、社会功能评分均高于治疗前（P＜0.05），且治疗组相关指标优于对照组（P＜0.05）。结论 红金消结胶囊联合左炔诺孕酮宫内缓释系统治疗子宫肌瘤可缩小子宫和肌瘤体积，降低月经出血量，提高生活质量，改善性激素水平。

Objective To investigate the clinical efficacy of Hongjin Xiaojie Capsules combined with Levonorgestrel-Releasing Intrauterine System in treatment of uterine fibroids. Methods Women (96 cases) with uterine fibroids in the 7th People’s Hospital of Zhengzhou from July 2021 to January 2023 were divided into control and treatment groups according to the random drawing method, and each group had 48 cases. Women in the control group received Levonorgestrel-Releasing Intrauterine System, and placed Levonorgestrel-Releasing Intrauterine System 3 - 5 d after menstruation, after shaving most of the endometrial, and the course of treatment was 3 months. Women in the treatment group were po administered with Hongjin Xiaojie Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies, menstrual blood loss, uterine volume, fibroid volume, quality of life, and serum sex hormone level in two groups were compared. Results After treatment, the total effective rate of the treatment group was higher than that of the control group (P < 0.05). After treatment, the amount of menstrual bleeding, uterine volume, and fibroid volume, and the serum levels of LH, FSH, P, and E₂in the two groups were lower than before treatment, the material living status score, physical function score, psychological function score, and social function score of two groups were higher than before treatment (P < 0.05), and the above indexes in the treatment group were better than those in the control group (P < 0.05). Conclusion Hongjin Xiaojie Capsules combined with Levonorgestrel- Releasing Intrauterine System in treatment of uterine fibroids can reduce the volume of uterus and fibroids, reduce menstrual bleeding, improve quality of life, and improve sex hormone levels.

R984

河南省医学科技攻关计划（联合共建）项目（LHGJ20191322）