目的 探讨桑枝总生物碱片联合德谷门冬双胰岛素注射液治疗2型糖尿病的临床疗效。方法 纳入2021年1月—2022年12月兴安盟人民医院108例2型糖尿病患者，以随机数表法分为对照组和治疗组，每组54例。对照组患者皮下注射德谷门冬双胰岛素注射液，1次/d，随每日最大一餐给药。治疗组患者在对照组基础上口服桑枝总生物碱片，1片/次，3次/d，嚼碎后与第一口或前几口食物一起服用。两组均连续治疗4周。比较两组的临床疗效、血糖指标、血糖波动指标和胰岛素功能指标。结果 治疗后，治疗组和对照组总有效率分别为94.44%、81.48%，组间比较差异有统计学意义（P＜0.05）。治疗后，两组空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbAlc）、血糖水平标准差（SDBG）、日间血糖平均绝对差（MODD）、平均血糖波动幅度（MAGE）均较治疗前降低（P＜0.05），且治疗组FPG、2 h PG、HbAlc、SDBG、MODD、MAGE更低（P＜0.05）。治疗后，两组空腹胰岛素（FINS）、胰岛β细胞功能指数（HOMA-β）均显著升高，胰岛素抵抗指数（HOMA-IR）均显著降低（P＜0.05），且治疗组患者FINS、HOMA-β均显著高于对照组，HOMA-IR低于对照组（P＜0.05）。结论 桑枝总生物碱片联合德谷门冬双胰岛素注射液素治疗2型糖尿病的临床疗效确切，可显著降低患者血糖，减少血糖波动，改善胰岛β细胞功能和胰岛素抵抗。

Objective To explore clinical effect of Mulberry Twig Alkaloids Tablets combined with Insulin Degludec and Insulin Aspart Injection in treatment of type 2 diabetes mellitus. Methods Patients (108 cases) with type 2 diabetes mellitus in Xing’an League People’s Hospital from January 2021 to December 2022 were divided into control and treatment groups according to the random number table method, and each group had 54 cases. Patients in the control group were sc injected with Insulin Degludec and Insulin Aspart Injection, once daily, taking the medicine with the largest meal of the day. Patients in the treatment group were po administered with Mulberry Twig Alkaloids Tablets on the basis of the control group, 1 tablets/time, three times daily, after chewing, taking it together with the first bite or first few bites of food. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies, blood glucose index, blood glucose fluctuation index, and insulin function index in two groups were compared. Results After treatment, the total effective rate of treatment group and control group was 94.44% and 81.48%, respectively, and the difference between groups was statistically significant (P < 0.05). After treatment, FPG, 2 h PG, HbAlc, SDBG, MODD, and MAGE in two groups were lower than those before treatment (P < 0.05), and FPG, 2 h PG, HbAlc, SDBG, MODD, and MAGE in treatment group were lower than those in the control group (P < 0.05). After treatment, FINS and HOMA-β in two groups were significantly increased, but HOMA-IR in two groups was significantly decreased (P < 0.05), and FINS and HOMA-β in the treatment group were significantly higher than those in the control group, while HOMA-IR in the treatment group was lower than that in the control group (P< 0.05). Conclusion Mulberry Twig Alkaloids Tablets combined with Insulin Degludec and Insulin Aspart Injection has a definite clinical effect in treatment of type 2 diabetes mellitus, can significantly reduce blood sugar in patients, reduce blood sugar fluctuations, improve islet β cell function and insulin resistance.

R977

内蒙古自治区科技计划项目（2020GG0253）