目的 探讨龙七胃康片联合艾司奥美拉唑肠溶胶囊治疗胃溃疡的临床效果。方法 选取2022年1月—2023年6月在郑州市第七人民医院接受治疗的胃溃疡患者94例，随机分为对照组（47例）和治疗组（47例）。对照组患者口服艾司奥美拉唑肠溶胶囊，20 mg/次，2次/d。治疗组患者在对照组的治疗基础上口服龙七胃康片，3片/次，3次/d。两组均治疗4周。观察两组的临床疗效、溃疡愈合情况、临床症状消失时间、胃泌素、C反应蛋白（CRP）、白细胞介素-17（IL-17）的水平。结果 治疗后，治疗组的总有效率为95.74%，显著高于对照组的80.85%（P＜0.05）。治疗后，治疗组溃疡愈合率为87.23%，显著高于对照组的70.21%（P＜0.05）。治疗组腹痛、反酸、嗳气消失时间均显著短于对照组（P＜0.05）。治疗后，两组胃泌素、CRP、IL-17水平均较同组治疗前显著明降低（P＜0.05）；且治疗后，治疗组患者的胃泌素、CRP、IL-17水平低于对照组（P＜0.05）。结论 龙七胃康片联合艾司奥美拉唑肠溶胶囊治疗胃溃疡具有较好的临床疗效，可有效促进溃疡愈合、缩短临床症状消失时间，改善机体的胃肠激素及炎症指标水平，且无明显的药物不良反应。

Objective To explore the therapeutic effect of Longqi Weikang Tablets combined with esomeprazole in treatment of gastric ulcers. Methods A total of 94 patients with gastric ulcer who received treatment in Zhengzhou Seventh People’s Hospital from January 2022 to June 2023 were randomly divided into control group (47 cases) and treatment group (47 cases). Patients in the control group were po administered with Esomeprazole Enteric Capsules, 20 mg/time, twice daily. Patients in the treatment group were po administered with Longqi Weikang Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. The clinical efficacy, ulcer healing, duration of clinical symptoms and the levels of gastrin, C-reactive protein (CRP) and interleukin-17 (IL-17) in two groups were observed. Results After treatment, the total effective rate of treatment group was 95.74%, which was significantly higher than that of control group (80.85%, P< 0.05). After treatment, the ulcer healing rate in treatment group was 87.23%, which was significantly higher than that in control group (70.21%) (P< 0.05). The disappearance time of abdominal pain, acid reflux and belching in treatment group was significantly shorter than that in control group (P< 0.05). After treatment, the levels of gastrin, CRP, and IL-17 in two groups were significantly decreased compared with before treatment (P < 0.05). After treatment, the levels of gastrin, CRP, and IL-17 in treatment group were lower than those in control group (P < 0.05). Conclusion Longqi Weikang Tablets combined with esomeprazole has good clinical efficacy in treatment of gastric ulcers, and can effectively promote ulcer healing, shorten the time for clinical symptom disappearance, improve the levels of gastrointestinal hormones and inflammatory indicators in the body, which has no obvious adverse drug reactions.

R975

河南省医学科技攻关省部共建青年项目（SBGJ202103106）