目的 探讨百咳宁颗粒联合布地奈德治疗小儿百日咳综合征的疗效及其对潮气呼吸肺功能的影响。方法 选取2020年1月—2022年12月河北省儿童医院收治的98例百日咳综合征患儿，采用随机数字表法将98例百日咳综合征患儿分为对照组和治疗组，每组各49例。对照组给予吸入用布地奈德混悬液，1 mL吸入用布地奈德混悬液与2 mL生理盐水混合，2次/d。治疗组在对照组治疗基础上口服百咳宁颗粒，患儿年龄≤1岁，1袋/次；1岁＜年龄≤3岁，1.5袋/次；年龄＞3岁，2袋/次，3次/d。两组患儿均连续治疗10 d。观察两组的临床疗效，比较两组治疗前后潮气呼吸肺功能及血清白细胞介素17（IL-17）、白细胞介素6（IL-6）、C反应蛋白（CRP）的变化情况。结果 治疗后，治疗组总有效率是95.92%，显著高于对照组的81.63%（P＜0.05）。治疗后，两组患儿公斤体质量潮气量、达峰容积比、达峰时间比均较同组治疗前明显上升（P＜0.05）；且治疗后，治疗组患儿公斤体质量潮气量、达峰容积比、达峰时间比显著大于对照组（P＜0.05）。治疗后，两组患儿血清IL-17、IL-6、CRP水平均较同组治疗前明显降低（P＜0.05）；且治疗后，治疗组患儿血清IL-17、IL-6、CRP水平显著低于对照组（P＜0.05）。治疗过程中，对照组和治疗组患者不良反应发生率分别是4.08%、8.16%，两组比较差异无统计学意义。结论 百咳宁颗粒联合布地奈德治疗小儿百日咳综合征安全有效，可明显改善患儿的潮气呼吸肺功能及呼吸道炎症反应，该方案可作为临床治疗小儿百日咳综合征的选择之一。

Objective To explore the efficacy of Baikening Granules combined with budesonide in treatment of pertussis syndrome in children and its impact on tidal breathing lung function.Methods A total of 98 children with pertussis syndrome admitted to Hebei Children’s Hospital from January 2020 to December 2022 were selected and divided into control group and treatment group by random number table method, with 49 cases in each group. Patients in the control group were given Budesonide Suspension for Inhalation, 1 mL of Budesonide Suspension for Inhalation mixed with 2 mL of normal saline, twice daily. Patients in the treatment group were po administered with Baikening Granules on the basis of the control group, children ≤1 year old, 1 bag/time; 1 year old < children ≤3 years old, 1.5 bags/time; children > 3 years old, 2 bags/time, 3 times daily. Both groups were treated continuously for 10 d. The clinical effects of two groups were observed, and the changes of tidal respiratory lung function and serum interleukin 17 (IL-17), interleukin 6 (IL-6) and C-reactive protein (CRP) before and after treatment were compared between two groups. Results After treatment, the total effective rate of treatment group was 95.92%, which was significantly higher than that of control group (81.63%, P < 0.05). After treatment, tidal volume per kilogram of body mass, peak-to-volume ratio and peak-to-time ratio in 2 groups were significantly increased compared with before treatment (P < 0.05). After treatment, the tidal volume per kg of body mass, peak-to-volume ratio and peak-to-time ratio in treatment group were significantly higher than those in control group (P < 0.05). After treatment, serum levels of IL-17, IL-6 and CRP in 2 groups were significantly lower than before treatment (P< 0.05). After treatment, the serum levels of IL-17, IL-6 and CRP in treatment group were significantly lower than those in control group (P< 0.05). In the course of treatment, the incidence of adverse reactions in control group and treatment group was 4.08% and 8.16%, respectively, and there was no statistical significance between the two groups. Conclusion Baikening Granules combined with budesonide is safe and effective in treatment of pertussis syndrome in children, and can obviously improve the moisture respiratory lung function and respiratory inflammatory response of children, which can be used as one of the options for clinical treatment of children with pertussis syndrome.

R974

河北省医学科学研究课题计划（20190799）