目的 探讨宣肺止嗽合剂联合头孢地尼治疗急性细菌性上呼吸道感染的临床疗效。方法 选取2021年6月—2023年6月上海交通大学医学院苏州九龙医院收治的急性细菌性上呼吸道感染患者120例，随机分为对照组（60例）和治疗组（60例）。对照组患者口服头孢地尼分散片，100 mg/次，3次/d。在对照组的基础上，治疗组口服宣肺止嗽合剂，20 mL/次，3次/d。两组连续服药7 d。观察两组患者临床疗效，比较治疗前后两组患者临床症状恢复时间，体温（T），白细胞计数（WBC），血清炎性因子白细胞介素-6（IL-6）、降钙素原（PCT）、干扰素-γ（INF-γ）和C反应蛋白（CRP）水平。结果 治疗后，治疗组临床总有效率为98.33%，明显高于对照组总有效率（83.33%，P＜0.05）。治疗后，治疗组症状好转时间均明显短于对照组（P＜0.05）。治疗后，两组患者体温、WBC、IL-6、PCT、CRP指标水平均比治疗前显著下降，而IFN-γ水平明显升高（P＜0.05），且治疗组这些指标水平均明显好于对照组（P＜0.05）。结论 头孢地尼与宣肺止嗽合剂协同治疗急性细菌性上呼吸道感染，可明显改善患者体温及症状，并能有效减弱上呼吸道炎性反应状态。

Objective To explore the clinical effect of Xuanfei Zhisou Mixture combined with cefdinib in treatment of acute bacterial upper respiratory tract infection. Methods Patients (120 cases) with acute bacterial upper respiratory tract infection in Suzhou Jiulong Hospital of Shanghai Jiaotong University School of Medicine from June 2021 to June 2023 were randomly divided into control (60 cases) and treatment (60 cases) group. Patients in the control group were po administered with Cefdinir Dispersible Tablets, 100 mg/time, three times daily. Patients in the treatment group were po administered with Xuanfei Zhisou Mixture on the basis of the control group, 20 mL/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, temperature (T), WBC, the levels of IL-6, PCT, CRP and IFN-γ in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 98.33%, which was significantly higher than that of the control group (83.33%, P < 0.05). After treatment, the time of symptom improvement in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the levels of T, WBC, IL-6, PCT and CRP in two groups were significantly lower than those before treatment, while the level of IFN-γ were significantly increased (P < 0.05), and the levels of these indexes in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The synergistic treatment of cefdinib and Xuanfei Zhisou Mixture can significantly improve the patient's body temperature and symptoms, and can effectively reduce the inflammatory state of the upper respiratory tract.

R974