目的 建立采用抑制电导离子色谱法测定醋酸钙颗粒中钙离子的方法。方法 采用Dionex IonPac^TM CS12A色谱柱（250 mm×4 mm），Dionex IonPac^TM CG12A保护柱（50 mm×4 mm），以0.02 mol/L甲烷磺酸溶液为洗脱液，体积流量1.0 mL/min，柱温30 ℃，检测池温度35 ℃，电导检测器，抑制器为Dionex CDRS 600 4 mm，电流值59 mA，进样体积为25 μL。结果 钙在0.002～6.000 μg/mL线性关系良好（r＝0.999 7），平均回收率为104.6%，RSD值为1.8%。结论 方法简单、专属性高、准确可靠，能够有效地控制醋酸钙颗粒中钙离子。

Objective To establish a method of ion chromatography-suppressed conductivity to determine calcium ion in Calcium Acetate Granules.Methods The assay was performed on Dionex IonPac^TM CS12A column (250 mm × 4 mm) with Dionex IonPac^TM CG12A column (50 mm × 4 mm) as guard column. Mobile phase was used as 0.02 mol/L methanesulfonic acid solution. Flow rate was 1.0 mL/min, column temperature was 30 ℃, and detecting pool temperature was 35 ℃. Conductivity detector was used with CDRS 600 4 mm as suppressor, current value was 59 mA, and injection volume was 25 μL. Results Calcium showed good linear relationships of 0.002 -6.000 μg/mL (r＝0.999 7), whose average recovery was 104.6% with RSD values of 1.8%. Conclusion The method is simple, highly specific, accurate and reliable, and can effectively control calcium ion in Calcium Acetate Granules.

R927.1