[关键词]
[摘要]
目的 探析康复新液联合注射用生长抑素治疗急性十二指肠溃疡出血的临床效果。方法 选取2020年1月—2022年1月中国人民解放军南部战区总医院诊治的106例急性十二指肠溃疡出血患者,以随机数字表法将所有患者分为对照组和治疗组,各53例。对照组首先缓慢静脉注射0.25 mg注射用生长抑素作为负荷剂量,而后立即静脉点滴0.25 mg/h。如果两次输液给药间隔大于3~5 min,采取重新静脉注射0.25 mg注射用生长抑素以确保给药的连续性。治疗组在对照组治疗的基础上口服康复新液,10 mL/次,3次/d。两组连续治疗7 d。比较两组的临床疗效、临床指标、血清炎性因子水平。结果 治疗后,治疗组总有效率为98.11%,显著高于对照组的总有效率83.02%(P<0.05)。治疗后,治疗组大便隐血转阴时间、禁食时间均短于对照组(P<0.05)。治疗后,两组血清白细胞介素-6(IL-6)水平均较治疗前下降(P<0.05);且治疗组的血清IL-6水平均低于对照组(P<0.05)。结论 康复新液联合注射用生长抑素治疗急性十二指肠溃疡出血的效果更显著,可有效改善临床症状、降低血清IL-6水平。
[Key word]
[Abstract]
Objective To explore the clinical effect of Kangfuxin Solution combined with Somatostatin for injection in treatment of acute duodenal ulcer bleeding. Methods Patients (106 cases) with acute duodenal ulcer bleeding in the General Hospital of the Southern Theater Command of the Chinese People’s Liberation Army from January 2020 to January 2022 were divided into control and treatment groups according to the random number table, and each group had 53 cases. Patients in the control group were first slowly injected with 0.25 mg Somatostatin for injection as loading dose, and then immediately intravenous dripped 0.25 mg/h. If the interval between infusion and infusion was greater than 3 to 5 minutes, 0.25 mg Somatostatin for injection was re-administered intravenously to ensure continuity of administration. Patients in the treatment group were po administered with Kangfuxin Solution on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 7 d. The clinical efficacies, the changes of clinical indexes, and inflammatory factor levels in two groups were compared. Results Compared with the control group (83.02%), total effective rate of the treatment group (98.11%) was significantly higher (P<0.05). Compared with control group, time of stool occult blood turning negative and fasting in the treatment group were shorter (P<0.05). After treatment, the serum levels of IL-6 in two groups decreased compared to before treatment (P<0.05), and those in the treatment group were lower than those in the control group (P< 0.05). Conclusion Kangfuxin Solution combined with Somatostatin for injection has a more significant effect on the treatment of acute duodenal ulcer bleeding, which can effectively improve clinical symptoms and reduce the serum level of IL-6.
[中图分类号]
R975
[基金项目]
广东省医学科学技术研究基金项目(B2022070)