目的 探讨加味左金丸联合雷贝拉唑治疗胃食管反流病的临床疗效。方法 选取2021年1月—2023年3月苏州高新区人民医院收治的胃食管反流病患者100例，随机分为对照组（50例）和治疗组（50例）。对照组患者口服雷贝拉唑肠溶胶囊，1次/d，20 mg/次。治疗组患者在对照组基础上口服加味左金丸，2次/d，6 g/次。两组均连续治疗8周。观察两组患者临床疗效，比较治疗前后两组患者临床症状和SF-36量表评分及食管括约肌静息压。结果 治疗后，治疗组总有效率为90.00%，明显高于对照组（74.00%，P＜0.05）。治疗后，两组反流性疾病问卷（RDQ）总分、烧心、反食、反酸、胸部不适评分均明显降低，而总体健康、生理功能、生理职能、社会功能、情感职能、躯体疼痛、生命活力、心理健康评分明显升高（P＜0.05），且治疗组临床症状和SF-36量表评分明显好于对照组（P＜0.05）。治疗后，两组患者食管下括约肌（LES）静息压和食管上括约肌（UES）静息压明显升高（P＜0.05），且治疗组明显高于对照组（P＜0.05）。结论 加味左金丸联合雷贝拉唑治疗胃食管反流病具有较好的疗效，可改善患者的临床症状和生活质量，增加食管括约肌静息压。

Objective To explore the curative effect of Jiawei Zuojin Pills combined with rabeprazole in treatment of gastroesophageal reflux disease. Methods Patients (100 cases) with gastroesophageal reflux disease in the People’s Hospital of SND from January 2021 to March 2023 were randomly divided into control (50 cases) and treatment (50 cases) group. Patients in the control group were po administered with Rabeprazole Sodium Enteric Capsules, 20 mg/time, once daily. Patients in the treatment group were po administered with Jiawei Zuojin Pills on the basis of the control group, 6 g/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, the scores of clinical symptom and SF-36 scale, resting pressure of esophageal sphincter in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 90.00%, which was significantly higher than that of the control group (74.00%, P＜0.05). After treatment, the total score of RDQ, the scores of heartburn, regurgitation, acid reflux and chest discomfort in two groups were significantly decreased, while the scores of overall health, physiological function, physiological function, social function, emotional function, physical pain, vitality and mental health were significantly increased (P＜0.05), and the clinical symptoms and the score of SF-36 scale in the treatment group were significantly better than those in the control group (P＜0.05). After treatment, the resting pressure of LES and UES in two groups were significantly increased (P＜0.05), and which in the treatment group were significantly higher than those in the control group (P＜0.05). Conclusion Jiawei Zuojin Pills combined with rabeprazole has good effect in the treatment of gastroesophageal reflux disease, which can improve the clinical symptoms and quality of life of patients, increase the resting pressure of esophageal sphincter.

R975

江苏省卫生健康委科研项目立项项目（M2020037）