目的 探讨小儿热速清颗粒联合奥司他韦治疗儿童流行性感冒的临床疗效。方法 选取2023年1月—5月北京市通州区妇幼保健院收治的98例流感患儿，按随机数字表法将所有患儿分为对照组和治疗组，每组各49例。对照组患儿口服磷酸奥司他韦颗粒，体质量≤15 kg者30 mg/次，15～23 kg者45 mg/次，23～40 kg者60 mg/次，＞40 kg者75 mg/次，均为2次/d，以温开水溶解后口服。治疗组在对照组基础上口服小儿热速清颗粒，1～3岁者1袋/次，3～7岁者1.5袋/次，7～12岁者2袋/次，均为3次/d。两组疗程均为5 d。观察两组患儿临床疗效、完全退热时间和流感样症状消失时间。比较治疗前后两组儿童生活质量量表4.0（Peds QLTM4.0）、90项症状自评量表（SCL-90）评分及血常规指标和C反应蛋白（CRP）水平。结果 治疗后，治疗组总有效率是95.92%，显著高于对照组的83.67%（P＜0.05）。治疗组完全退热时间和肌痛、头痛、全身不适、咳嗽、咽喉痛的消失时间均显著短于对照组（P＜0.05）。治疗后，两组Peds QLTM4.0评分均显著增加，而SCL-90评分均显著降低（P＜0.05）；治疗后，治疗组患儿Peds QLTM4.0、SCL-90评分改善优于对照组（P＜0.05）。治疗后，两组淋巴细胞计数（LYMP#）均显著增加，而中性粒细胞计数（NEUT#）、单核细胞计数（MONO#）和CRP水平均显著下降（P＜0.05）；治疗后，血常规指标和CRP水平均以治疗组改善更显著（P＜0.05）。结论 小儿热速清颗粒联合奥司他韦治疗儿童流行性感冒效果确切，可迅速减轻症状，利于控制机体炎症反应、增强免疫力及改善患儿生活质量和心理状态，值得临床推广应用。

Objective To explore the clinical efficacy of Xiao’er Resuqing Granules combined with oseltamivir in treatment of influenza in children. Methods A total of 98 children with influenza treated in Beijing Tongzhou District maternal and Child Health Hospital from January to May 2023 were selected and divided into control group and treatment group according to random number table method, with 49 cases in each group. Children in control group were po administered with Oseltamivir Phosphate Granules, body weight ≤15 kg 30 mg/time, 15 — 23 kg 45 mg/time, 23 — 40 kg 60 mg/time, and ＞ 40 kg 75 mg/time, twice daily, Oseltamivir Phosphate Granules were dissolved in warm water and taken orally. Children in treatment group were po administered with Xiao’er Resuqing Granules on the basis of control group, 1 bag/time for 1 to 3 years old, 1.5 bags/time for 3 to 7 years old, 2 bags/time for 7 to 12 years old, 3 times daily. The treatment course of both groups was 5 d. The clinical effect, the time of complete fever remission and the time of disappearance of flu-like symptoms were observed in two groups. Quality of Life Scale 4.0 (Peds QLTM4.0), 90-item Symptom Checklist 90 (SCL-90) scores, blood routine indexes and C-reactive protein (CRP) levels were compared between two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 95.92%, which was significantly higher than that of the control group (83.67%, P＜0.05). The complete remission time of fever and the disappearance time of myalgia, headache, general discomfort, cough and sore throat in treatment group were significantly shorter than those in control group (P＜0.05). After treatment, Peds QLTM4.0 was significantly increased in both groups, but SCL-90 score was significantly decreased in both groups (P＜0.05). After treatment, Peds QLTM4.0 and SCL-90 scores in treatment group were better than those in control group (P＜0.05). After treatment, the lymphocyte count (LYMP#) was significantly increased, but the neutrophil count (NEUT#), monocyte count (MONO#) and CRP levels were significantly decreased in both groups (P＜0.05). After treatment, blood routine indexes and CRP levels were significantly improved in treatment group (P＜0.05). Conclusion Xiao’er Resuqing Granules combined with oseltamivir has a definite effect in treatment of influenza in children, can rapidly reduce symptoms, help control inflammation, enhance immunity and improve the life quality and psychological state of children, which is worthy of clinical promotion and application.

R974

北京市通州区科技计划项目（KJ2022CX051）