[关键词]
[摘要]
目的 探讨注射用益气复脉(冻干)联合环磷腺苷葡胺注射液治疗慢性心力衰竭的临床疗效。方法 选取2020年4月—2022年1月河南大学第一附属医院收治的慢性心力衰竭患者216例,按照随机数字表法将患者分为对照组(108例)和治疗组(108例)。对照组静脉滴注环磷腺苷葡胺注射液60~180 mg,加入200~500 mL 5%葡萄糖注射液稀释,1次/d。治疗组在对照组的基础上静脉滴注注射用益气复脉(冻干),8瓶/次,用5%葡萄糖注射液或生理盐水250~500 mL稀释,1次/d。两组患者均治疗2周。比较两组总有效率、心功能指标、心肌重构指标、运动耐力和血清炎症因子指标。结果 治疗后,治疗组的总有效率94.44%高于对照组的总有效率82.41%(P<0.05)。治疗后,两组的左心室射血分数(LVEF)、心输出量(CO)均显著升高(P<0.05),治疗组的LVEF、CO均高于对照组(P<0.05)。治疗后,两组左心房内径(LAP)、左室舒张末内径(LVEDD)、左室质量指数(LVMI)均显著下降,左室重构指数(LVRI)升高(P<0.05);治疗组的LAP、LVEDD、LVMI低于对照组,LVRI高于对照组(P<0.05)。治疗后,两组6 min步行试验(6 MWT)显著升高(P<0.05),治疗组的6 MWT显著高于对照组(P<0.05)。治疗后,两组血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、N端前脑钠肽(NT-proBNP)水平下降,治疗组血清hs-CRP、IL-6、TNF-α、NT-proBNP水平较对照组低(P<0.05)。结论 注射用益气复脉(冻干)与环磷腺苷葡胺注射液联合治疗慢性心力衰竭患者可有效改善心功能和心肌重构,降低炎症因子水平。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Yiqi Fumai (lyophilized) for injection combined with Meglumine Adenosine Cyclophosphate Injection in treatment of chronic heart failure. Methods Patients (216 cases) with chronic heart failure in the First Affiliated Hospital of Henan University from April 2020 to January 2022 were divided into control and treatment groups according to random number tablet method, and each group had 108 cases. Patients in the control group were iv administered with Meglumine Adenosine Cyclophosphate Injection, 60 — 80 mg added into 5% glucose injection 200 — 500 mL, once daily. Patients in the treatment group were iv administered with Yiqi Fumai (lyophilized) for injection on the basis of the control group, 8 bottles added into 5% glucose injection 250 — 500 mL, once daily. Patients in two groups were treated for 2 weeks. The clinical efficacies, cardiac function indicators, myocardial remodeling indicators, exercise endurance, and serum inflammatory factor indicators in two groups were compared. Results After treatment, the total effective rate of 94.44% in the treatment group was higher than that of 82.41% in the control group (P<0.05). After treatment, LVEF and CO of two groups significantly increased (P<0.05), and LVEF and CO of the treatment group were higher than those of the control group (P<0.05). After treatment, LAP, LVEDD, and LVMI in two groups significantly decreased, while LVRI in two groups significantly increased (P< 0.05). LAP, LVEDD, and LVMI in the treatment group were lower than those in the control group, while LVRI in the treatment group was higher than those in the control group (P<0.05). After treatment, 6 MWT of two groups significantly increased (P<0.05), and 6 MWT of the treatment group was significantly higher than that of the control group (P< 0.05). After treatment, the serum levels of hs-CRP, IL-6, TNF-α, and NT-proBNP in two groups decreased, and the serum levels of hs-CRP, IL-6, TNF-α, and NT-proBNP in the treatment group were lower than those in the control group (P<0.05). Conclusion Yiqi Fumai (lyophilized) for injection combined with Meglumine Adenosine Cyclophosphate Injection has a good effect in the treatment of patients with chronic heart failure, which can effectively improve heart function and myocardial remodeling, and reduce levels of inflammatory factors.
[中图分类号]
R972
[基金项目]
开封市科技发展计划项目(2203021)