目的 建立左甲状腺素钠片药物利用评价细则，探讨AHM赋权联合TOPSIS法在左甲状腺素钠片药物利用合理性评价中的应用。方法 制定左甲状腺素钠片药物利用评价标准，采用层次分析-逼近理想解排序（AHP-TOPSIS）法，对宁德师范学院附属宁德市医院2021年1月—2023年3月使用左甲状腺素钠片患者的用药合理性进行评价。结果 共抽取276份病历，其中相对接近度（C_i）≥90%的占0.36%（1份），80%≤C_i＜90%的占10.14%（28份），70%≤C_i＜80%的占17.75%（49份），60%≤C_i＜70%的占51.09%（141份），50%≤C_i＜60%的占18.12%（50份），C_i＜50%的占2.54%（7份）。左甲状腺素钠片不合理用药主要体现在给药时间间隔、给药时间、实验室检查、给药剂量、适应证等方面。结论 通过AHM-TOPSIS建立了左甲状腺素钠片临床应用合理性评价方法，所建立的方法切实可行。

Objective To establish thedetailed rules for evaluating drug utilization of levothyroxine sodium tablets by AHM-TOPSIS method to provide references for its clinical rational application. Methods Establishing the drug utilization review standard of levothyroxine sodium tablets. According to this standard rules to analyze and evaluate the rationality of 276 prescriptions with levothyroxine sodium tablets from Jan. 2021 to Mar. 2023 by AHP-TOPSIS method. Results Among 276 medical records evaluated by levothyroxine sodium tablets. There were 1 cases (0.36%) with C_i ≥ 90%, 28 cases (10.14%) with C_i 80% — 90%, 49 cases (17.75%) with C_i 70% — 80%, 141 cases (51.09%) with C_i 60% — 70%, 50 cases (18.12%) with C_i 50% — 60%, and 7 case (2.54%) with C_i < 50%. The irrational use of levothyroxine sodium tablets was mainly reflected in aspects such as administration time interval, administration time, laboratory examination, dosage, indications, and indications. Conclusion The rationality evaluation method of clinical application of levothyroxine sodium tablets is established by AHM-TOPSIS method, and the method is feasible.

R977

福建省科技厅引导性项目（2018Y0047）