目的 探讨糖脉康颗粒联合度拉糖肽注射液治疗2型糖尿病的临床效果。方法 选取2021年5月—2023年4月在北京市第六医院收治的102例2型糖尿病患者，根据计算机随机排列将所有患者分为对照组和治疗组，各包括51例。对照组给予度拉糖肽注射液，起始剂量1次/周，1支/次，根据血糖水平调整剂量，维持剂量1次/周，1～2支/次。治疗组在对照组基础上口服糖脉康颗粒，3次/d，1袋/次。两组在治疗3个月后分析疗效。比较两组患者的临床疗效、血糖指标、血糖波动情况、血管内皮功能和血清指标。结果 治疗后，治疗组的总有效率高达92.16%，明显高于对照组的76.47%（P＜0.05）。治疗后，两组患者的空腹血糖（FBG）、糖化血红蛋白（HbA1c）均显著下降（P＜0.05）。治疗后，两组的平均血糖波动幅度、血糖标准差、餐后血糖波动幅度明显降低（P＜0.05），且治疗组的平均血糖波动幅度、血糖标准差、餐后血糖波动幅度均明显低于对照组（P＜0.05），两组的血管内皮功能指数（FMD）均显著升高（P＜0.05），治疗组的FMD明显高于对照组（P＜0.05）。治疗后，两组的血清内脂素（visfatin）、内皮素-1（ET-1）水平显著降低（P＜0.05），治疗组的血清visfatin、ET-1水平低于对照组（P＜0.05）。结论 糖脉康颗粒联合度拉糖肽注射液可提高2型糖尿病的疗效，有效降低血糖水平和血糖波动，改善血管内皮功能。

Objective To investigate the clinical effect of Tangmaikang Granules combined with Dulaglutide Injection in treatment of type 2 diabetes mellitus. Methods Patients (102 cases) with type 2 diabetes mellitus in Beijing Sixth Hospital from May 2021 to April 2023 were divided into control and treatment groups according to computer random arrangement method, and each group had 51 cases. Patients in the control group were given Dulaglutide Injection, the initial dose was 1 dose/time, once weekly, and the dose was adjusted according to the blood glucose level, and the maintenance dose was once weekly, and the dose was 1 — 2 dose/time. Patients in the treatment group were po administered with Tangmaikang Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 3 months. The clinical efficacies, blood glucose indexes, blood glucose fluctuation, vascular endothelial function indexes, and serum indexes in two groups were compared. Results After treatment, the total effective rate of the treatment group was 92.16%, which was significantly higher than that of the control group (76.47%, P < 0.05). After treatment, FBG and HbA1c in two groups were significantly decreased (P < 0.05). After treatment, the mean blood glucose fluctuation range, blood glucose standard deviation and postprandial blood glucose fluctuation range of two groups were significantly reduced (P < 0.05), and the mean blood glucose fluctuation range, blood glucose standard deviation, and postprandial blood glucose fluctuation range of the treatment group were significantly lower than those of the control group (P < 0.05). After treatment, FMD in two groups was significantly increased (P < 0.05), and FMD in the treatment group was significantly higher than that in the control group (P < 0.05). After treatment, the serum levels of visfatin and ET-1 in two groups were significantly decreased (P < 0.05), and the serum levels of visfatin and ET-1 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Tangmaikang Granules combined with Dulaglutide Injection can improve the therapeutic effect of type 2 diabetes mellitus, effectively reduce blood glucose level and blood glucose fluctuation, improves vascular endothelial function.

R977

北京市东城区卫生科技计划项目[东卫健研（2019）]