目的 探讨注射用头孢哌酮舒巴坦钠联合注射用替加环素治疗多重耐药肺炎克雷伯菌肺炎的应用效果。方法 选取2020年1月—2022年12月铜陵市人民医院收治的76例多重耐药肺炎克雷伯菌肺炎患者作为研究对象，按随机数字表法将所有患者分为对照组和治疗组，各38例。对照组静脉滴注注射用替加环素，50 mg/次，1次/12 h。治疗组在对照组治疗基础上静脉滴注注射用头孢哌酮钠舒巴坦钠，2 g/次，生理盐水100 mL稀释，1次/6 h。两组均连续治疗7 d。比较两组的临床疗效、细菌清除情况和血清炎症指标。结果 治疗后，治疗组的临床治愈率为78.95%，明显高于对照组的临床治愈率55.26%（P＜0.05）。治疗后，治疗组的细菌清除率为81.58%，明显高于对照组的细菌清除率55.26%（P＜0.05）。治疗后，两组血清指标C-反应蛋白（CRP）、白细胞介素-6（IL-6）和降钙素原（PCT）水平均降低（P＜0.05），且治疗组血清炎症指标低于对照组（P＜0.05）。结论 注射用头孢哌酮舒巴坦钠联合注射用替加环素治疗多重耐药肺炎克雷伯菌肺炎的效果显著，有效提高细菌清除率，减轻机体炎症反应。

Objective To investigate the effect of Cefoperazone Sodium and Sulbactam Sodium for injection combined with Tigecycline for injection in treatment of multidrug-resistant Klebsiella pneumoniae pneumonia. Methods Patients (76 cases) with multidrug-resistant Klebsiella pneumoniae pneumonia in Tongling People’s Hospital from January 2020 to December 2022 were divided into control and treatment groups according to random number table method, and each group had 38 cases. Patients in the control group were iv Tigecycline for injection, 50 mg/time, once every 12 h. Patients in the treatment group were iv Cefoperazone Sodium and Sulbactam Sodium for injection on the basis of the control group, 2 g/time, diluted with 100 mL normal saline, once every 6 h. Patients in two groups were treated for 7 d. The clinical efficacies, bacterial clearance, and serum inflammatory indexes in two groups were compared. Results After treatment, the clinical cure rate of the treatment group was 78.95%, which was significantly higher than that of the control group 55.26% (P < 0.05). After treatment, the bacterial clearance rate of the treatment group was 81.58%, which was significantly higher than 55.26% of the control group (P < 0.05). After treatment, the serum levels of CRP, IL-6, and PCT in two groups were decreased (P < 0.05), and the serum inflammation indexes in the treatment group were lower than those in the control group (P < 0.05). Conclusion Cefoperazone Sodium and Sulbactam Sodium for injection combined with Tigecycline for injection has a significant effect in treatment of multidrug-resistant Klebsiella pneumoniae pneumonia, which can effectively improve the bacterial clearance rate, reduce the inflammatory reaction of the body.

R974

安徽省危重症呼吸疾病临床医学研究中心开放课题（LC202201）