目的 探讨保和丸联合复方消化酶胶囊治疗功能性消化不良的临床疗效。方法 选取2018年3月—2022年12月重庆市中医院收治的78例功能性消化不良患者，按随机数字表法将所有患者分为对照组和治疗组，每组各39例。对照组饭后口服复方消化酶胶囊，2粒/次，3次/d。治疗组在对照组基础上口服保和丸，2丸/次，2次/d。两组疗程均为4周。观察两组的临床疗效，比较治疗前后两组主要症状积分、功能性消化不良生存质量量表（FDDQL）评分、简明尼平消化不良指数（SF-NDI）评分及胃排空指标。结果 治疗后，治疗组患者总有效率是97.44%较之对照组的79.49%显著提高（P＜0.05）。治疗后，两组餐后饱胀不适、上腹痛、早饱感、上腹烧灼感积分及其总积分均显著降低（P＜0.05）；且治疗后以治疗组降低更显著（P＜0.05）。治疗后，两组患者FDDQL评分均显著增加，而SF-NDI评分均显著下降（P＜0.05）；且均以治疗组改善更显著（P＜0.05）。治疗后，两组胃半排空时间均显著缩短，胃窦收缩幅度及收缩频率均显著增加（P＜0.05）；且均以治疗组改善更显著（P＜0.05）。结论 保和丸联合复方消化酶胶囊治疗功能性消化不良的整体疗效确切，能安全有效地减轻患者症状，促进胃排空，改善生活质量。

Objective To explore the clinical efficacy of Baohe Pills combined with Compound Digestive Enzyme Capsules in treatment of functional dyspepsia. Methods A total of 78 patients with functional dyspepsia admitted to Chongqing Hospital of Traditional Chinese Medicine from March 2018 to December 2022 were selected and divided into control group and treatment group according to random number table method, with 39 cases in each group. Patients in the control group were po administered with Compound Digestive Enzyme Capsules, 2 grains/time, three times daily. Patients in the treatment group were po administered with Baohe Pills on the basis of the control group, 2 pills/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the scores of major symptoms, Functional dyspepsia Quality of Life Scale (FDDQL), concise nipine dyspepsia index (SF-NDI) and gastric emptying indexes were compared between the two groups before and after treatment. Results After treatment, the total effective rate of the treatment group was 97.44%, which was significantly higher than that of the control group (79.49%, P < 0.05). After treatment, the scores of postprandial fullness and discomfort, epigastric pain, early satiety and epigastric burning were significantly decreased in both groups (P < 0.05). After treatment, the reduction was more significant in the treatment group (P < 0.05). After treatment, FDDQL scores were significantly increased in both groups, while SF-NDI scores were significantly decreased in both groups (P < 0.05). The improvement was more significant in the treatment group (P < 0.05). After treatment, the gastric half-emptying time was significantly shortened, and the contraction amplitude and frequency of gastric antrum were significantly increased in both groups (P < 0.05). The improvement was more significant in the treatment group (P < 0.05). Conclusion Baohe Pills combined with Compound Digestive Enzyme Capsules has a definite overall therapeutic effect in treatment of functional dyspepsia, and can safely and effectively reduce the symptoms of patients, promote gastric emptying and improve the quality of life.

R975