目的 探讨桃红清血丸联合卡泊三醇治疗白癜风的临床疗效。方法 选取2021年3月—2023年3月河南省中医院收治的90例白癜风患者，随机法分对照组（45例）和治疗组（45例）。对照组患者外涂卡泊三醇软膏，每次2 mg/cm²，2次/d。在对照组的基础上，治疗组口服桃红清血丸，15丸/次，2次/d。两组患者治疗8周。观察两组患者临床疗效，比较治疗前后两组患者皮损面积好转，皮肤病生活质量指数（DLQI）评分，血清炎性因子干扰素-γ（IFN-γ）、白细胞介素-6（IL-6）、白细胞介素-17A（IL-17A）和肿瘤坏死因子-α（TNF-α）水平。结果 治疗后，治疗组患者临床有效率为97.78%，明显高于对照组有效率（82.22%，P＜0.05）。治疗2、4、8周后，治疗组皮损面积好转均小于对照组（P＜0.05）。治疗后，两组患者DLQI评分均明显下降（P＜0.05），且治疗组DLQI评分明显低于对照组（P＜0.05）。治疗后，两组血清炎性因子IL-6、IL-17A和TNF-α水平明显降低，而IFN-γ水平明显升高（P＜0.05），且治疗组IL-6、IL-17A、TNF-α和IFN-γ水平明显好于对照组（P＜0.05）。结论 桃红清血丸联合卡泊三醇治疗白癜风效果确切，可增强局部皮损血液微循环，促进皮损面积缩小，并使临床疗效提高。

Objective To explore the clinical effect of Taohong Qingxue Pills combined with carpotriol in treatment of vitiligo. Methods Patients (90 cases) with vitiligo in Henan Provincial Hospital of Traditional Chinese Medicine from March 2021 to March 2023 were randomly divided into control (45 cases) and treatment (45 cases) group. Patients in the control group were administered with Calcipotriol Ointment, 2 mg/cm² at a time, twice daily. Patients in the treatment group were po administered with Taohong Qingxue Pills on the basis of the control group, 15 pills/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, and the improvement in skin lesion area, DLQI scores, the levels of serum IL-6, IL-17A, TNF-α and IFN-γ in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.78%, which was significantly higher than that of the control group (82.22%, P < 0.05). After 2 weeks, 4 weeks and 8 weeks of treatment, the area of skin lesions in the treatment group was smaller than that in the control group (P< 0.05). After treatment, the DLQI score in two groups was significantly decreased, and the DLQI score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the levels of serum inflammatory factors IL-6, IL-17A and TNF-α were significantly decreased, while the level of IFN- γ was significantly increased in two groups (P< 0.05), and the levels of IL-6, IL-17A, TNF-α and IFN- γ in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The synergistic effect of carpotriol and Taohong Qingxue Pills is effective, which can enhance the blood microcirculation of local skin lesions, reduce the area of skin lesions, and improve the clinical curative effect.

R986

河南省中医药科学研究专项课题（2021JDZX2104）