目的 观察疏风解毒胶囊联合孟鲁司特钠和丙酸氟替卡松治疗儿童痰热郁结型腺样体肥大的临床疗效。方法 选取2022年5月—2023年3月安徽中医药大学第一附属医院收治的70例痰热郁结型腺样体肥大的患儿，随机分为对照组（35例）和治疗组（35例）。对照组患儿口服孟鲁司特钠颗粒，4 mg/次，1次/d，以及喷鼻丙酸氟替卡松鼻喷雾剂，每侧鼻孔50μg/次，2次/d。治疗组患儿在上述方案的基础上口服疏风解毒胶囊，0.52 g/次，3次/d。两组患儿均治疗6周。观察两组患儿临床疗效，比较治疗前后两组患儿中医证候主症和次症单项积分，腺样体厚度/鼻咽腔宽度比值（A/N）积分，OSA-18积分和复发率。结果 治疗后，治疗组临床有效率为93.94%，明显高于对照组（75.00%，P＜0.05）。治疗后，两组中医证候主症和次症单项积分，及A/N值和OSA-18积分均低于本组治疗前（P＜0.05），且治疗组各项积分下调水平更加显著（P＜0.05）。治疗1个月后，治疗组复发率明显低于对照组（3.23% vs 20.83%，P＜0.05）。结论 疏风解毒胶囊联合孟鲁司特钠和丙酸氟替卡松治疗儿童痰热郁结型腺样体肥大疗效确切，可有效缓解症状，缩小腺样体指数，提高生活质量，且安全性好，预后近期复发率较低。

Objective To observe the clinical efficacy of Shufeng Jiedu Capsules combined with montelukast sodium and fluticasone propionate in treatment of adenoid hypertrophy of phlegm-heat stagnation in children. Methods Children (70 cases) with adenoid hypertrophy of phlegm-heat in the First Affiliated Hospital of Anhui University of Chinese Medicine from May 2022 to March 2023 were randomly divided into control (35 cases) and treatment (35 cases) group. Children in the control group were po administered with Montelukast Sodium Oral Granules, 4 mg/time, once daily, and they were administered with Fluticasone Propionate Nasal Spray, 50 μg/time for each nostril, twice daily. Children in the treatment group were po administered with Shufeng Jiedu Capsules on the basis of the control group, 0.52 g/time, three times daily. Children in two groups were treated for 6 weeks. After treatment, the clinical evaluation was evaluated, and the scores of TCM primary and secondary symptoms, scores of A/N value and OSA-18, and recurrence rate in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 93.94%, which was significantly higher than that of the control group (75.00%, P < 0.05). After treatment, the scores of main syndrome and secondary syndrome, A/N value and OSA-18 score in two groups were lower than those before treatment (P < 0.05), and the down-regulation level of each score in the treatment group was more significant (P < 0.05). After one month of treatment, The recurrence rate in the treatment group was significantly lower than that in the control group (3.23% vs 20.83%, P < 0.05). Conclusion Shufeng Jiedu Capsules combined with montelukast sodium and fluticasone propionate has a definite curative effect in treatment of adenoid hypertrophy of phlegm-heat stagnation in children, which can effectively relieve the symptoms, reduce the adenoid index, improve the quality of life, and the safety is good, and the short-term recurrence rate is low.

R985

安徽省名中医工作室建设项目[中发展（2020）10号]