目的 探讨补血益母丸联合甲羟孕酮治疗药物流产后阴道不规则出血的疗效。方法 选取2021年2月—2023年2月海口市第四人民医院收治的80例药物流产后阴道不规则出血患者，随机分为对照组（40例）和治疗组（40例）。对照组患者口服醋酸甲羟孕酮片，4 mg/次，2次/d。在对照组的基础上，治疗组口服补血益母丸，12 g/次，2次/d。两组患者服用7 d。观察两组患者临床疗效，比较治疗前后两组患者流产后阴道出血情况，子宫内膜厚度和子宫容积，孕酮（P）、促卵泡生成素（FSH）、人绒毛膜促性腺激素（HCG）、黄体生成素（LH）水平。结果 治疗后，治疗组临床有效率为97.50%，明显高于对照组有效率（85.03%，P＜0.05）。治疗后，治疗组阴道出血持续时间、阴道出血量均明显少于对照组（P＜0.05）。治疗后，两组患者子宫内膜厚度、子宫容积比治疗前明显增加（P＜0.05），且治疗组患者子宫内膜厚度、子宫容积均优于对照组（P＜0.05）。治疗后，两组性激素HCG、FSH、P、LH水平比治疗前明显降低（P＜0.05），且治疗组患者明显低于对照组（P＜0.05）。结论 补血益母丸联合甲羟孕酮治疗药物流产后阴道不规则出血效果确切，能有效改善阴道出血情况，并有效恢复子宫宫腔状态，促进性激素水平调节。

Objective To investigate the therapeutic effect of Buxue Yimu Pills combined with medroxyprogesterone in treatment of irregular vaginal bleeding after medical abortion. Methods Patients (80 cases) with irregular vaginal bleeding after medical abortion in the Fourth People's Hospital of Haikou from February 2021 to February 2023 were randomly divided into control (40 cases) and treatment (40 cases) group. Patients in the control group were po administered with Medroxyprogesterone Acetate Tablets, 4 mg/time, twice daily. Patients in the treatment group were po administered with Buxue Yimu Pills on the basis of the control group, 12 g/time, twice daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluation was evaluated, and the vaginal bleeding volume, endometrial thickness and uterine, HCG, FSH, P and LH levels in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.50%, which was significantly higher than that of the control group (85.03%, P < 0.05). After treatment, the duration and volume of vaginal bleeding in the treatment group were significantly less than those in the control group (P < 0.05). After treatment, the endometrial thickness and uterine volume in two groups were significantly higher than those before treatment (P < 0.05), and the endometrial thickness and uterine volume in the treatment group were better than those in the control group (P < 0.05). After treatment, the levels of HCG, FSH, P and LH in two groups were significantly lower than those before treatment, and which in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion The synergistic treatment of medroxyprogesterone and Buxue Yimu Pill has a definite effect, which can effectively improve the situation of vaginal bleeding, effectively restore the state of uterine cavity and promote the regulation of sex hormone level.

R984