目的 探讨热淋清颗粒联合注射用头孢哌酮钠舒巴坦钠治疗急性肾盂肾炎的临床疗效。方法 选取2020年5月—2023年4月在唐山市中医医院就诊的70例急性肾盂肾炎患者，根据计算机随机排列将所有患者分为对照组和治疗组，每组各35例。对照组静脉滴注注射用头孢哌酮钠舒巴坦钠，将3 g加入100 mL生理盐水充分稀释后，滴注30～60 min，1次/d。治疗组在对照组基础上口服热淋清颗粒，2袋/次，3次/d。两组患者连续治疗2周。观察两组的总有效率，比较两组患者的发热、尿路刺激征、腰痛消失时间，急性生理学与健康状况评分量表（APACHE Ⅱ）评分变化，以及超敏C反应蛋白（hs-CRP）、白细胞介素-8（IL-8）、降钙素原（PCT）、β₂-微球蛋白（β₂-MG）、胱抑素C（Cys-C）的水平。结果 治疗后，治疗组的总有效率94.29%明显高于对照组的总有效率77.14%，组间比较差异显著（P＜0.05）。治疗后，治疗组患者发热、尿路刺激征、腰痛消失时间短于对照组，差异有统计学意义（P＜0.05）。治疗后，两组的APACHE II评分低于治疗前（P＜0.05），且治疗组的APACHE II评分低于对照组（P＜0.05）。治疗后，两组的血清hs-CRP、IL-8、PCT水平低于治疗前（P＜0.05），且治疗组的血清hs-CRP、IL-8、PCT水平低于对照组，差异有统计学意义（P＜0.05）。治疗后，两组的β₂-MG、Cys-C水平低于治疗前（P＜0.05），且治疗组的β₂-MG、Cys-C水平低于对照组（P＜0.05）。结论 热淋清颗粒联合注射用头孢哌酮钠舒巴坦钠可提高急性肾盂肾炎的疗效，减轻病情严重程度和临床症状，降低炎症反应，改善患者肾功能。

Objective To investigate the clinical effect of Relinqing Granules combined with Cefoperazone Sodium and Sulbactam Sodium for injection in treatment of acute pyelonephritis. Methods Patients (70 cases) with acute pyelonephritis in Tangshan Hospital of Traditional Chinese Medicine from May 2020 to April 2023 were divided into control and treatment groups according to the computer random arrangement method, and each group had 35 cases. Patients in the control group were iv administered with Cefoperazone Sodium and Sulbactam Sodium for injection, 3 g added into normal saline 100 mL, infusion 30 — 60 min, once daily. Patients in the treatment group were po administered with Relinqing Granules on the basis of the control group, 2 bags/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the disappearance time of fever, urinary tract irritation sign, and low back pain, APACHE II scores, the levels of hs-CRP, IL-8, PCT, β₂-MG, and Cys-C in two groups were compared. Results After treatment, the total effective rate of 94.29% in the treatment group was significantly higher than 77.14% in the control group, with significant differences between the groups (P < 0.05). After treatment, the disappearance time of fever, urinary tract irritation and low back pain in the treatment group was shorter than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, APACHE II scores in two groups were lower than before treatment (P < 0.05), and APACHE II scores in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of hs-CRP, IL-8, and PCT in two groups were lower than before treatment (P < 0.05), and the serum levels of hs-CRP, IL-8, and PCT in the treatment group were lower than those in the control group after treatment with statistical significance (P < 0.05). After treatment, the levels of β₂-MG and Cys-C in two groups were lower than before treatment (P < 0.05), and the levels of β₂-MG and Cys-C in the treatment group were lower than those in the control group (P < 0.05). Conclusion Relinqing Granules combined with Cefoperazone Sodium and Sulbactam Sodium for injection can improve the curative effect of acute pyelonephritis, reduce the severity of the disease and clinical symptoms, reduce inflammatory response, and improve patients’ kidney function.

R983

河北省中医药管理局科研计划项目（2015232）